| Literature DB >> 20057513 |
Kazuro Shiomi1, Ryosuke Matsui, Atsuo Kakei, Yuichi Yamaguchi, Rokuro Masuma, Hiroko Hatano, Noriko Arai, Miki Isozaki, Haruo Tanaka, Susumu Kobayashi, Andreas Turberg, Satoshi Omura.
Abstract
A new ryanodine-binding inhibitor, verticilide, was isolated from the cultured broth of a fungus, Verticillium sp. FKI-1033. It is a 24-membered ring cyclic depsipeptide, its structure being elucidated as cyclo[(2R)-2-hydroxyheptanoyl-N-methyl- L-alanyl](4). Verticilide inhibited ryanodine binding to ryanodine receptors in the cockroach at an IC(50) value of 4.2 microM, whereas inhibition against mouse ryanodine receptors was weak (IC(50)=53.9 microM).Entities:
Mesh：
Substances：
Year: 2010 PMID： 20057513 DOI： 10.1038/ja.2009.126
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649