Literature DB >> 20057412

The saving switch.

Cassandra Willyard.   

Abstract

The epigenome consists of a system of chemical tags that attach to our DNA and its associated molecules, switching genes on and off. But the system is not without glitches-and scientists think that the misplacement of these tags can cause disease. This idea has led to new drugs that aim to correct gene activity (and obliterate disease) by altering the proteins around which DNA winds. Cassandra Willyard examines whether this approach will unlock the long-awaited promise of epigenetic therapy.

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Year:  2010        PMID： 20057412     DOI： 10.1038/nm0110-18

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  10 in total

1.  Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

Authors:  V M Richon; Y Webb; R Merger; T Sheppard; B Jursic; L Ngo; F Civoli; R Breslow; R A Rifkind; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

2.  Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: stimulation of erythroid differentiation by dimethyl sulfoxide.

Authors:  C Friend; W Scher; J G Holland; T Sato
Journal:  Proc Natl Acad Sci U S A       Date:  1971-02       Impact factor: 11.205

3.  Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.

Authors:  Mario F Fraga; Esteban Ballestar; Ana Villar-Garea; Manuel Boix-Chornet; Jesus Espada; Gunnar Schotta; Tiziana Bonaldi; Claire Haydon; Santiago Ropero; Kevin Petrie; N Gopalakrishna Iyer; Alberto Pérez-Rosado; Enrique Calvo; Juan A Lopez; Amparo Cano; Maria J Calasanz; Dolors Colomer; Miguel Angel Piris; Natalie Ahn; Axel Imhof; Carlos Caldas; Thomas Jenuwein; Manel Esteller
Journal:  Nat Genet       Date:  2005-03-13       Impact factor: 38.330

4.  Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors.

Authors:  J S Ungerstedt; Y Sowa; W-S Xu; Y Shao; M Dokmanovic; G Perez; L Ngo; A Holmgren; X Jiang; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-06       Impact factor: 11.205

5.  A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

Authors:  V M Richon; S Emiliani; E Verdin; Y Webb; R Breslow; R A Rifkind; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

6.  Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Authors:  J S Steffan; L Bodai; J Pallos; M Poelman; A McCampbell; B L Apostol; A Kazantsev; E Schmidt; Y Z Zhu; M Greenwald; R Kurokawa; D E Housman; G R Jackson; J L Marsh; L M Thompson
Journal:  Nature       Date:  2001-10-18       Impact factor: 49.962

7.  The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.

Authors:  Elizabeth A Thomas; Giovanni Coppola; Paula A Desplats; Bin Tang; Elisabetta Soragni; Ryan Burnett; Fuying Gao; Kelsey M Fitzgerald; Jenna F Borok; David Herman; Daniel H Geschwind; Joel M Gottesfeld
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-30       Impact factor: 11.205

8.  Reprogramming of a melanoma genome by nuclear transplantation.

Authors:  Konrad Hochedlinger; Robert Blelloch; Cameron Brennan; Yasuhiro Yamada; Minjung Kim; Lynda Chin; Rudolf Jaenisch
Journal:  Genes Dev       Date:  2004-08-01       Impact factor: 11.361

9.  Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications.

Authors:  Constantine S Mitsiades; Nicholas S Mitsiades; Ciaran J McMullan; Vassiliki Poulaki; Reshma Shringarpure; Teru Hideshima; Masaharu Akiyama; Dharminder Chauhan; Nikhil Munshi; Xuesong Gu; Charles Bailey; Marie Joseph; Towia A Libermann; Victoria M Richon; Paul A Marks; Kenneth C Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2003-12-26       Impact factor: 11.205

10.  Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel.

Authors:  Lanlan Shen; Yutaka Kondo; Saira Ahmed; Yanis Boumber; Kazuo Konishi; Yi Guo; Xinli Chen; Jill N Vilaythong; Jean-Pierre J Issa
Journal:  Cancer Res       Date:  2007-12-01       Impact factor: 12.701
  10 in total
  6 in total

Review 1.  The epigenomic interface between genome and environment in common complex diseases.

Authors:  Christopher G Bell; Stephan Beck
Journal:  Brief Funct Genomics       Date:  2010-11-08       Impact factor: 4.241

2.  Epigenetic modulation of the renal β-adrenergic-WNK4 pathway in salt-sensitive hypertension.

Authors:  ShengYu Mu; Tatsuo Shimosawa; Sayoko Ogura; Hong Wang; Yuzaburo Uetake; Fumiko Kawakami-Mori; Takeshi Marumo; Yutaka Yatomi; David S Geller; Hirotoshi Tanaka; Toshiro Fujita
Journal:  Nat Med       Date:  2011-04-17       Impact factor: 53.440

3.  [Epigentics in rheumatic diseases].

Authors:  A Jüngel; S Gay
Journal:  Z Rheumatol       Date:  2011-04       Impact factor: 1.372

Review 4.  Epigenetic modifications: basic mechanisms and role in cardiovascular disease.

Authors:  Diane E Handy; Rita Castro; Joseph Loscalzo
Journal:  Circulation       Date:  2011-05-17       Impact factor: 29.690

Review 5.  HDAC inhibition in lupus models.

Authors:  Christopher M Reilly; Nicole Regna; Nilamadhab Mishra
Journal:  Mol Med       Date:  2011-02-11       Impact factor: 6.354

6.  Epigenetic modifications in hyperhomocysteinemia: potential role in diabetic retinopathy and age-related macular degeneration.

Authors:  Khaled Elmasry; Riyaz Mohamed; Isha Sharma; Nehal M Elsherbiny; Yutao Liu; Mohamed Al-Shabrawey; Amany Tawfik
Journal:  Oncotarget       Date:  2018-01-29
  6 in total

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