Literature DB >> 20057137

Inhibitory effect of curcumin on IMP dehydrogenase, the target for anticancer and antiviral chemotherapy agents.

Issei Dairaku1, Yunkyung Han, Noriyuki Yanaka, Norihisa Kato.   

Abstract

Inosine monophosphate dehydrogenase (IMPDH), a rate-limiting enzyme in the de novo synthesis of guanine nucleotides, is a therapeutic target for anticancer and antiviral agents. Among the 15 different polyphenols examined, curcumin was found to have an inhibitory effect on the IMPDH activity in both a competitive and uncompetitive manner and to suppress the cellular GTP level in HT-29 colon carcinoma cells.

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Year:  2010        PMID： 20057137     DOI： 10.1271/bbb.90568

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  7 in total

Review 1.  Multitargeting by curcumin as revealed by molecular interaction studies.

Authors:  Subash C Gupta; Sahdeo Prasad; Ji Hye Kim; Sridevi Patchva; Lauren J Webb; Indira K Priyadarsini; Bharat B Aggarwal
Journal:  Nat Prod Rep       Date:  2011-10-06       Impact factor: 13.423

Review 2.  The targets of curcumin.

Authors:  Hongyu Zhou; Christopher S Beevers; Shile Huang
Journal:  Curr Drug Targets       Date:  2011-03-01       Impact factor: 3.465

Review 3.  Edible Bioactive Film with Curcumin: A Potential "Functional" Packaging?

Authors:  Josemar Gonçalves Oliveira Filho; Mariana Buranelo Egea
Journal:  Int J Mol Sci       Date:  2022-05-18       Impact factor: 6.208

4.  Proliferation inhibition, cell cycle arrest and apoptosis induced in HL-60 cells by a natural diterpene ester from Daphne mucronata.

Authors:  K Nouri; R Yazdanparast
Journal:  Daru       Date:  2011       Impact factor: 3.117

5.  The sonodynamic effect of curcumin on THP-1 cell-derived macrophages.

Authors:  Fengping Wang; Qianping Gao; Shuyuan Guo; Jiali Cheng; Xin Sun; Qiannan Li; Tengyu Wang; Zhiguo Zhang; Wenwu Cao; Ye Tian
Journal:  Biomed Res Int       Date:  2012-12-30       Impact factor: 3.411

Review 6.  A review on antibacterial, antiviral, and antifungal activity of curcumin.

Authors:  Soheil Zorofchian Moghadamtousi; Habsah Abdul Kadir; Pouya Hassandarvish; Hassan Tajik; Sazaly Abubakar; Keivan Zandi
Journal:  Biomed Res Int       Date:  2014-04-29       Impact factor: 3.411

Review 7.  Curcumin and Photobiomodulation in Chronic Viral Hepatitis and Hepatocellular Carcinoma.

Authors:  Laura Marinela Ailioaie; Gerhard Litscher
Journal:  Int J Mol Sci       Date:  2020-09-28       Impact factor: 5.923
  7 in total

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