| Literature DB >> 20056300 |
Livio Pagano1, Morena Caira, Caterina Giovanna Valentini, Brunella Posteraro, Luana Fianchi.
Abstract
Invasive fungal infections are significant causes of morbidity and mortality in patients with hematological malignancies. Patients with acute myeloid leukemia and those who have undergone allogeneic hematopoietic stem cell transplantation are at especially high risk. Various fungal agents are responsible for this complication, but Aspergillus spp. and Candida spp. are the most frequently isolated micro-organisms; less commonly, infections could be caused by Zygomycetes or other rare molds or yeasts. Several new systemically-administered antifungal agents have been approved for clinical use since 2001; these agents include liposomal amphotericin B, voriconazole, caspofungin, and posaconazole, and they represent a major advance in antifungal therapy and have improved the prognosis of patients with hematological malignancies. This review focuses on therapeutic aspects of the management of fungal infections in hematological patients. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20056300 DOI： 10.1016/j.blre.2009.11.003
Source DB: PubMed Journal: Blood Rev ISSN： 0268-960X Impact factor: 8.250