OBJECTIVE: To investigate the proportions of CD4+CD25high T cells and forkhead box p3 (FOXP3) expression in peripheral blood and decidua in patients with unexplained recurrent spontaneous abortion (URSA). DESIGN: Prospective clinical study. SETTING: University hospital. PATIENT(S): 125 URSA patients, 35 normal early pregnant women, and 28 normal nonpregnant women. INTERVENTION(S): Measurements of CD4+CD25high T cells and FOXP3 expression in peripheral blood and decidua. MAIN OUTCOME MEASURE(S): The proportions of CD4+CD25high T cells and FOXP3 expression. RESULT(S): In peripheral blood, statistically significantly higher proportions of CD4+CD25high T cells and FOXP3 expression were observed in normal early pregnant women compared with normal nonpregnant women and URSA patients; a statistically significantly lower proportion of CD4+CD25high T cells was observed in nonpregnant URSA patients compared with URSA patients who had early miscarriages and normal nonpregnant women. In the decidua, statistically significantly lower proportions of CD4+CD25high T cells and FOXP3 expression were found in URSA patients with early miscarriages compared with normal early pregnant women. CONCLUSION(S): The CD4+CD25high T cells may play an important role in maintaining a normal pregnancy. The reduction in CD4+CD25high T cells may involve in the pathogenesis of URSA, and is correlated with lower FOXP3 expression.
OBJECTIVE: To investigate the proportions of CD4+CD25high T cells and forkhead box p3 (FOXP3) expression in peripheral blood and decidua in patients with unexplained recurrent spontaneous abortion (URSA). DESIGN: Prospective clinical study. SETTING: University hospital. PATIENT(S): 125 URSA patients, 35 normal early pregnant women, and 28 normal nonpregnant women. INTERVENTION(S): Measurements of CD4+CD25high T cells and FOXP3 expression in peripheral blood and decidua. MAIN OUTCOME MEASURE(S): The proportions of CD4+CD25high T cells and FOXP3 expression. RESULT(S): In peripheral blood, statistically significantly higher proportions of CD4+CD25high T cells and FOXP3 expression were observed in normal early pregnant women compared with normal nonpregnant women and URSA patients; a statistically significantly lower proportion of CD4+CD25high T cells was observed in nonpregnant URSA patients compared with URSA patients who had early miscarriages and normal nonpregnant women. In the decidua, statistically significantly lower proportions of CD4+CD25high T cells and FOXP3 expression were found in URSA patients with early miscarriages compared with normal early pregnant women. CONCLUSION(S): The CD4+CD25high T cells may play an important role in maintaining a normal pregnancy. The reduction in CD4+CD25high T cells may involve in the pathogenesis of URSA, and is correlated with lower FOXP3 expression.
Authors: Tony T Jiang; Vandana Chaturvedi; James M Ertelt; Jeremy M Kinder; Dayna R Clark; Amy M Valent; Lijun Xin; Sing Sing Way Journal: J Immunol Date: 2014-06-01 Impact factor: 5.422