Literature DB >> 20055795

Efficient utilization of the expanded criteria donor (ECD) deceased donor kidney pool: an analysis of the effect of labeling.

R A Hirth1, Q Pan, D E Schaubel, R M Merion.   

Abstract

We investigated the effect of the expanded criteria donor (ECD) label on (i) recovery of kidneys and (ii) acceptance for transplantation given recovery. An ECD is age > or = 60, or age 50-59 with > or = 2 of 3 specified comorbidities. Using data from the Scientific Registry of Transplant Recipients from 1999 to 2005, we modeled recovery rates through linear regression and transplantation probabilities via logistic regression, focusing on organs from donors just-younger versus just-older than the ECD age thresholds. We split the sample at July 1, 2002 to determine how decisions changed at the approximate time of implementation of the ECD definition. Before July 2002, the number of recovered kidneys with 0-1 comorbidities dropped at age 60, but transplantation probabilities given recovery did not. After July 2002, the number of recovered kidneys with 0-1 comorbidities rose at age 60, but transplantation probabilities contingent on recovery declined. No similar trends were observed at donor age 50 among donors with > or = 2 comorbidities. Overall, implementation of the ECD definition coincided with a reversal of an apparent reluctance to recover kidneys from donors over age 59, but increased selectiveness on the part of surgeons/centers with respect to these kidneys.

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Year:  2010        PMID: 20055795      PMCID: PMC4456011          DOI: 10.1111/j.1600-6143.2009.02937.x

Source DB:  PubMed          Journal:  Am J Transplant        ISSN: 1600-6135            Impact factor:   8.086


  10 in total

1.  Matching does not improve outcome from aged marginal kidney donors.

Authors:  E J Alfrey; A D Lu; J T Carter; D C Dafoe
Journal:  Transplant Proc       Date:  2001 Feb-Mar       Impact factor: 1.066

2.  A positive analysis of financial incentives for cadaveric organ donation.

Authors:  M M Byrne; P Thompson
Journal:  J Health Econ       Date:  2001-01       Impact factor: 3.883

3.  It is time to re-think 'extended criteria'.

Authors:  R B Freeman; G B Klintmalm
Journal:  Am J Transplant       Date:  2006-08-21       Impact factor: 8.086

4.  Report of the Crystal City meeting to maximize the use of organs recovered from the cadaver donor.

Authors:  Bruce R Rosengard; Sandy Feng; Edward J Alfrey; Jonathan G Zaroff; Jean C Emond; Mitchell L Henry; Edward R Garrity; John P Roberts; James J Wynn; Robert A Metzger; Richard B Freeman; Friedrich K Port; Robert M Merion; Robert B Love; Ronald W Busuttil; Francis L Delmonico
Journal:  Am J Transplant       Date:  2002-09       Impact factor: 8.086

5.  Public education and organ donation.

Authors:  G G Persijn; A R van Netten
Journal:  Transplant Proc       Date:  1997 Feb-Mar       Impact factor: 1.066

6.  Using a standardized donor ratio to assess the performance of organ procurement organizations.

Authors:  Sheryl Stogis; Richard A Hirth; Robert L Strawderman; Jane Banaszak-Holl; Dean G Smith
Journal:  Health Serv Res       Date:  2002-10       Impact factor: 3.402

7.  The expanded criteria donor policy: an evaluation of program objectives and indirect ramifications.

Authors:  J D Schold; R J Howard; M J Scicchitano; H-U Meier-Kriesche
Journal:  Am J Transplant       Date:  2006-07       Impact factor: 8.086

8.  Financial incentives for cadaver organ donation: an ethical reappraisal.

Authors:  Robert Arnold; Steven Bartlett; James Bernat; John Colonna; Donald Dafoe; Nancy Dubler; Scott Gruber; Jeffrey Kahn; Richard Luskin; Howard Nathan; Susan Orloff; Jeffrey Prottas; Robyn Shapiro; Camillo Ricordi; Stuart Youngner; Francis L Delmonico
Journal:  Transplantation       Date:  2002-04-27       Impact factor: 4.939

9.  Impact of the expanded criteria donor allocation system on the use of expanded criteria donor kidneys.

Authors:  Randall S Sung; Mary K Guidinger; Craig D Lake; Maureen A McBride; Stuart M Greenstein; Francis L Delmonico; Friedrich K Port; Robert M Merion; Alan B Leichtman
Journal:  Transplantation       Date:  2005-05-15       Impact factor: 4.939

10.  Donor characteristics associated with reduced graft survival: an approach to expanding the pool of kidney donors.

Authors:  Friedrich K Port; Jennifer L Bragg-Gresham; Robert A Metzger; Dawn M Dykstra; Brenda W Gillespie; Eric W Young; Francis L Delmonico; James J Wynn; Robert M Merion; Robert A Wolfe; Philip J Held
Journal:  Transplantation       Date:  2002-11-15       Impact factor: 4.939

  10 in total
  4 in total

1.  Novel Application of Localized Nanodelivery of Anti-Interleukin-6 Protects Organ Transplant From Ischemia-Reperfusion Injuries.

Authors:  Z Solhjou; M Uehara; B Bahmani; O H Maarouf; T Ichimura; C R Brooks; W Xu; M Yilmaz; A Elkhal; S G Tullius; I Guleria; M M McGrath; R Abdi
Journal:  Am J Transplant       Date:  2017-04-18       Impact factor: 8.086

2.  Availability, utilization and outcomes of deceased diabetic donor kidneys; analysis based on the UNOS registry.

Authors:  S Mohan; B Tanriover; N Ali; R J Crew; G K Dube; J Radhakrishnan; M A Hardy; L E Ratner; W McClellan; D Cohen
Journal:  Am J Transplant       Date:  2012-07-03       Impact factor: 8.086

3.  Epidemiology of Kidney Discard from Expanded Criteria Donors Undergoing Donation after Circulatory Death.

Authors:  Sunita K Singh; S Joseph Kim
Journal:  Clin J Am Soc Nephrol       Date:  2015-12-14       Impact factor: 8.237

Review 4.  Stem/Stromal Cells for Treatment of Kidney Injuries With Focus on Preclinical Models.

Authors:  Adriana Torres Crigna; Cristina Daniele; Carolina Gamez; Sara Medina Balbuena; Diego O Pastene; Daniela Nardozi; Cinzia Brenna; Benito Yard; Norbert Gretz; Karen Bieback
Journal:  Front Med (Lausanne)       Date:  2018-06-15
  4 in total

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