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Literature DB >> 20055716

Targeting DAX-1 in embryonic stem cells and cancer.

Abstract

IMPORTANCE OF THE FIELD: DAX-1 (NR0B1) is an unusual orphan nuclear receptor whose function is essential for the development of the human adrenal cortex and onset of puberty. Recent data have implicated this transcription factor also in embryonic stem cell and cancer biology. AREAS COVERED IN THIS REVIEW: The role of DAX-1 in the regulation of development and function of the adrenal cortex, reproductive axis, embryonic stem cells and a few types of cancer. WHAT THE READER WILL GAIN: Here we review the past and present milestones in DAX-1 research and try to provide hints about the development and fields of application of DAX-1-targeted drugs in the future. TAKE HOME MESSAGE: The unusual structure and restricted expression pattern of DAX-1 may offer unique opportunities for drug discovery.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20055716 DOI： 10.1517/14728220903531454

Source DB: PubMed Journal: Expert Opin Ther Targets ISSN： 1472-8222 Impact factor: 6.902

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Cited

12 in total

1. Role of SF-1 and DAX-1 during differentiation of P19 cells by retinoic acid.

Authors: Bryan W Teets; Kenneth J Soprano; Dianne Robert Soprano
Journal: J Cell Physiol Date: 2012-04 Impact factor: 6.384

2. Nuclear receptor 4A (NR4A) family - orphans no more.

Authors: Stephen Safe; Un-Ho Jin; Benjamin Morpurgo; Ala Abudayyeh; Mandip Singh; Ronald B Tjalkens
Journal: J Steroid Biochem Mol Biol Date: 2015-04-23 Impact factor: 4.292

Review 3. Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.

Authors: Stephen Safe; Un-Ho Jin; Erik Hedrick; Alexandra Reeder; Syng-Ook Lee
Journal: Mol Endocrinol Date: 2013-12-02

4. Phosphoenolpyruvate carboxykinase and glucose-6-phosphatase are required for steroidogenesis in testicular Leydig cells.

Authors: Seung Won Ahn; Gil-Tae Gang; Surendar Tadi; Balachandar Nedumaran; Yong Deuk Kim; Ji Hoon Park; Gi Ryang Kweon; Seung-Hoi Koo; Keesook Lee; Ryun-Sup Ahn; Yong-Hyeon Yim; Chul-Ho Lee; Robert A Harris; Hueng-Sik Choi
Journal: J Biol Chem Date: 2012-10-16 Impact factor: 5.157

5. DAX-1 Expression in Pediatric Rhabdomyosarcomas: Another Immunohistochemical Marker Useful in the Diagnosis of Translocation Positive Alveolar Rhabdomyosarcoma.

Authors: Calogero Virgone; Enzo Lalli; Gianni Bisogno; Elena Lazzari; Josep Roma; Angelica Zin; Elena Poli; Giovanni Cecchetto; Patrizia Dall'Igna; Rita Alaggio
Journal: PLoS One Date: 2015-07-13 Impact factor: 3.240

Targeting DAX-1 in embryonic stem cells and cancer.

1. Role of SF-1 and DAX-1 during differentiation of P19 cells by retinoic acid.

2. Nuclear receptor 4A (NR4A) family - orphans no more.

Review 3. Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.

4. Phosphoenolpyruvate carboxykinase and glucose-6-phosphatase are required for steroidogenesis in testicular Leydig cells.

5. DAX-1 Expression in Pediatric Rhabdomyosarcomas: Another Immunohistochemical Marker Useful in the Diagnosis of Translocation Positive Alveolar Rhabdomyosarcoma.

6. Methodological pitfalls in the study of DAX-1 function.

7. microRNA-181 promotes prostate cancer cell proliferation by regulating DAX-1 expression.

Review 8. Lipid-sensors, enigmatic-orphan and orphan nuclear receptors as therapeutic targets in breast-cancer.

Review 9. EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma.

10. Dax1 and Nanog act in parallel to stabilize mouse embryonic stem cells and induced pluripotency.