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Literature DB >> 20055707

Mechanisms of cell protection by heme oxygenase-1.

Raffaella Gozzelino¹, Viktoria Jeney, Miguel P Soares.

Abstract

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe(2+), carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism underlying this cytoprotective effect relies on the ability of HO-1 to catabolize free heme and prevent it from sensitizing cells to undergo programmed cell death. This cytoprotective effect inhibits the pathogenesis of a variety of immune-mediated inflammatory diseases.

Entities: Chemical Gene

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Year: 2010 PMID： 20055707 DOI： 10.1146/annurev.pharmtox.010909.105600

Source DB: PubMed Journal: Annu Rev Pharmacol Toxicol ISSN： 0362-1642 Impact factor: 13.820

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Cited

437 in total

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5. Oxidative stress fuels Trypanosoma cruzi infection in mice.

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Mechanisms of cell protection by heme oxygenase-1.

1. Upregulation of transcription factor NRF2-mediated oxidative stress response pathway in rat brain under short-term chronic hypobaric hypoxia.

2. Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system: insights for transition to Alzheimer's disease.

3. Host defense against malaria favors Salmonella.

4. Peroxyacetyl nitrate-induced oxidative and calcium signaling events leading to cell death in ozone-sensitive tobacco cell-line.

5. Oxidative stress fuels Trypanosoma cruzi infection in mice.

6. Suppression of ferroportin expression by cadmium stimulates proliferation, EMT, and migration in triple-negative breast cancer cells.

Review 7. Modulation of oxidative stress as an anticancer strategy.

8. Alcohol Upregulation of CYP2A5: Role of Reactive Oxygen Species.

9. Soy isoflavone antagonizes the oxidative cerebrovascular injury induced by β-amyloid peptides 1-42 in rats.

10. A knockdown with smoke model reveals FHIT as a repressor of Heme oxygenase 1.