Literature DB >> 20055428

Titanocene difluorides with improved cytotoxic activity.

Silvia Eger1, Timo A Immel, James Claffey, Helge Müller-Bunz, Matthias Tacke, Ulrich Groth, Thomas Huhn.   

Abstract

Titanocene difluorides can be obtained by halide metathesis of the respective titanocene dichlorides with trimethyltin fluoride (Me(3)SnF), giving access to a new class of cytotoxic active substances. Furthermore, an improved method for the synthesis of diaryl-substituted titanocene dichlorides is presented.

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Year:  2010        PMID： 20055428     DOI： 10.1021/ic9022163

Source DB:  PubMed          Journal:  Inorg Chem        ISSN： 0020-1669            Impact factor:   5.165


  8 in total

1.  Titanocene-phosphine derivatives as precursors to cytotoxic heterometallic TiAu2 and TiM (M = Pd, Pt) compounds. Studies of their interactions with DNA.

Authors:  Jose F González-Pantoja; Michael Stern; Andrzej A Jarzecki; Eva Royo; Elisa Robles-Escajeda; Armando Varela-Ramírez; Renato J Aguilera; María Contel
Journal:  Inorg Chem       Date:  2011-09-29       Impact factor: 5.165

2.  Regulation of the aggregation behavior of human islet amyloid polypeptide fragment by titanocene complexes.

Authors:  Weihong Du; Gehui Gong; Wenji Wang; Jufei Xu
Journal:  J Biol Inorg Chem       Date:  2017-08-11       Impact factor: 3.358

3.  Cytotoxicity of a Ti(IV) compound is independent of serum proteins.

Authors:  Arthur D Tinoco; Horatio R Thomas; Christopher D Incarvito; Alan Saghatelian; Ann M Valentine
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-12       Impact factor: 11.205

4.  Evaluation of cytotoxic activity of titanocene difluorides and determination of their mechanism of action in ovarian cancer cells.

Authors:  Lucie Koubkova; Rostislav Vyzula; Jindrich Karban; Jiri Pinkas; Eva Ondrouskova; Borivoj Vojtesek; Roman Hrstka
Journal:  Invest New Drugs       Date:  2015-07-24       Impact factor: 3.850

5.  Cytotoxic properties of titanocenyl amides on breast cancer cell line mcf-7.

Authors:  Li Ming Gao; Enrique Meléndez
Journal:  Met Based Drugs       Date:  2010-05-04

6.  In Search for Titanocene Complexes with Improved Cytotoxic Activity: Synthesis, X-Ray Structure, and Spectroscopic Study of Bis(eta-cyclopentadienyl)difluorotitanium(IV).

Authors:  Elias Koleros; Theocharis C Stamatatos; Vassilis Psycharis; Catherine P Raptopoulou; Spyros P Perlepes; Nikolaos Klouras
Journal:  Bioinorg Chem Appl       Date:  2010-06-23       Impact factor: 7.778

7.  Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice.

Authors:  Timo A Immel; Ulrich Groth; Thomas Huhn; Peter Öhlschläger
Journal:  PLoS One       Date:  2011-03-21       Impact factor: 3.240

8.  Synthesis, spectral characterization, and antiproliferative studies of mixed ligand titanium complexes of adamantylamine.

Authors:  Raj Kaushal; Nitesh Kumar; Ashun Chaudhary; Saroj Arora; Pamita Awasthi
Journal:  Bioinorg Chem Appl       Date:  2014-02-27       Impact factor: 7.778
  8 in total

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