Literature DB >> 20053814

RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans.

Zhuoyu Ni1, Siu Sylvia Lee.   

Abstract

Our understanding of the genetic mechanisms of organismal aging has advanced dramatically during the past two decades. With the development of large-scale RNAi screens, the last few years saw the remarkable identifications of hundreds of new longevity genes in the roundworm Caenorhabditis elegans. The various RNAi screens revealed many biological pathways previously unknown to be related to aging. In this review, we focus on findings from the recent large-scale RNAi longevity screens, and discuss insights they have provided into the complex biological process of aging and considerations of the RNAi technology will continue to have on the future development of the aging field.

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Year:  2010        PMID： 20053814      PMCID： PMC3096447          DOI： 10.1093/bfgp/elp051

Source DB:  PubMed          Journal:  Brief Funct Genomics        ISSN： 2041-2649            Impact factor:   4.241


  89 in total

1.  Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.

Authors:  Blanka Rogina; Stephen L Helfand; Stewart Frankel
Journal:  Science       Date:  2002-11-29       Impact factor: 47.728

2.  pWormgatePro enables promoter-driven knockdown by hairpin RNA interference of muscle and neuronal gene products in Caenorhabditis elegans.

Authors:  Michael Briese; Behrooz Esmaeili; Nicholas M Johnson; David B Sattelle
Journal:  Invert Neurosci       Date:  2006-01-24

3.  RNAi in C. elegans: soaking in the genome sequence.

Authors:  H Tabara; A Grishok; C C Mello
Journal:  Science       Date:  1998-10-16       Impact factor: 47.728

4.  daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans.

Authors:  K Lin; J B Dorman; A Rodan; C Kenyon
Journal:  Science       Date:  1997-11-14       Impact factor: 47.728

5.  Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice.

Authors:  Xingxing Liu; Ning Jiang; Bryan Hughes; Eve Bigras; Eric Shoubridge; Siegfried Hekimi
Journal:  Genes Dev       Date:  2005-09-29       Impact factor: 11.361

6.  The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors:  M Kaeberlein; M McVey; L Guarente
Journal:  Genes Dev       Date:  1999-10-01       Impact factor: 11.361

7.  The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.

Authors:  Kailiang Jia; Di Chen; Donald L Riddle
Journal:  Development       Date:  2004-07-14       Impact factor: 6.868

8.  The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway.

Authors:  S Ogg; G Ruvkun
Journal:  Mol Cell       Date:  1998-12       Impact factor: 17.970

9.  Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.

Authors:  Pankaj Kapahi; Brian M Zid; Tony Harper; Daniel Koslover; Viveca Sapin; Seymour Benzer
Journal:  Curr Biol       Date:  2004-05-25       Impact factor: 10.834

10.  4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila.

Authors:  Brian M Zid; Aric N Rogers; Subhash D Katewa; Misha A Vargas; Marysia C Kolipinski; Tony Au Lu; Seymour Benzer; Pankaj Kapahi
Journal:  Cell       Date:  2009-10-02       Impact factor: 41.582
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  14 in total

1.  The lifespan-extending effects of Nymphaea hybrid root extract in the nematode Caenorhabditis elegans.

Authors:  Ziheng Zhuang; Ting Lv; Min Li; Yusi Zhang; Ting Xue; Linsong Yang; Hui Liu; Weiming Zhang
Journal:  Plant Foods Hum Nutr       Date:  2014-12       Impact factor: 3.921

Review 2.  A network perspective on metabolism and aging.

Authors:  Quinlyn A Soltow; Dean P Jones; Daniel E L Promislow
Journal:  Integr Comp Biol       Date:  2010-07-12       Impact factor: 3.326

Review 3.  RNAi screening: new approaches, understandings, and organisms.

Authors:  Stephanie E Mohr; Norbert Perrimon
Journal:  Wiley Interdiscip Rev RNA       Date:  2011-09-22       Impact factor: 9.957

4.  Two SET domain containing genes link epigenetic changes and aging in Caenorhabditis elegans.

Authors:  Zhuoyu Ni; Atsushi Ebata; Elham Alipanahiramandi; Siu Sylvia Lee
Journal:  Aging Cell       Date:  2012-01-19       Impact factor: 9.304

5.  Metabolome and proteome changes with aging in Caenorhabditis elegans.

Authors:  Neil Copes; Clare Edwards; Dale Chaput; Mariam Saifee; Iosif Barjuca; Daniel Nelson; Alyssa Paraggio; Patrick Saad; David Lipps; Stanley M Stevens; Patrick C Bradshaw
Journal:  Exp Gerontol       Date:  2015-09-21       Impact factor: 4.032

Review 6.  Lessons from C. elegans: signaling pathways for longevity.

Authors:  Louis R Lapierre; Malene Hansen
Journal:  Trends Endocrinol Metab       Date:  2012-08-30       Impact factor: 12.015

7.  Double-Strand RNA (dsRNA) Delivery Methods in Insects: Diaphorina citri.

Authors:  Yulica Santos-Ortega; Alex Flynt
Journal:  Methods Mol Biol       Date:  2022

8.  Genome-scale RNA interference screen identifies antizyme 1 (OAZ1) as a target for improvement of recombinant protein production in mammalian cells.

Authors:  Su Xiao; Yu Chi Chen; Eugen Buehler; Swati Mandal; Ajeet Mandal; Michael Betenbaugh; Myung Hee Park; Scott Martin; Joseph Shiloach
Journal:  Biotechnol Bioeng       Date:  2016-09-21       Impact factor: 4.530

9.  The homeobox protein CEH-23 mediates prolonged longevity in response to impaired mitochondrial electron transport chain in C. elegans.

Authors:  Ludivine Walter; Aiswarya Baruah; Hsin-Wen Chang; Heather Mae Pace; Siu Sylvia Lee
Journal:  PLoS Biol       Date:  2011-06-21       Impact factor: 8.029

10.  Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans.

Authors:  Alfonso Schiavi; Alessandro Torgovnick; Alison Kell; Evgenia Megalou; Natascha Castelein; Ilaria Guccini; Laura Marzocchella; Sara Gelino; Malene Hansen; Florence Malisan; Ivano Condò; Roberto Bei; Shane L Rea; Bart P Braeckman; Nektarios Tavernarakis; Roberto Testi; Natascia Ventura
Journal:  Exp Gerontol       Date:  2012-12-13       Impact factor: 4.032
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