OBJECTIVES: Exposures during prenatal period have implications for pregnancy outcome as well as for children's health, morbidity and mortality. Prospective cohort study design allows for the identification of exposures that may influence pregnancy outcome and children's health, verification of such exposures by biomarker measurements and notification of any changes in exposure level. MATERIALS AND METHODS: Polish Mother and Child Cohort Study (REPRO_PL) is multicenter prospective cohort study conducted in 8 different regions of Poland. The final cohort is intended to comprise 1300 mother-child pairs to be recruited within 4-year period (2007-2011). The recruitment and all scheduled visits are conducted in maternity units or clinics in the districts included in the study. The women are followed-up 3 times in pregnancy (once in each trimester) and after delivery for the notification of pregnancy outcome. During each visit, detailed questionnaire and biological samples are collected including saliva, urine, hair, maternal blood and cord blood. About 6 weeks postpartum, breast milk from part of the women is collected. The study concentrates on the identification and evaluation of the effects of prenatal environmental exposure on pregnancy outcome and children's health. Specific research hypotheses refer to the role of heavy metals, exposure to polycyclic aromatic hydrocarbons (PAHs) and environmental tobacco smoke (ETS) in the aetiology of small-for-gestational-age (SGA) and preterm delivery (PD). The role of oxidative stress putative mechanism and pregnant women nutritional status will be investigated. Based on questionnaire data, the impact of occupational exposures and stressful situations will be evaluated. RESULTS: The results of the study will become available within the next few years and will help to determine levels of child prenatal exposure in several areas of Poland and its impact on course and outcome of pregnancy.
OBJECTIVES: Exposures during prenatal period have implications for pregnancy outcome as well as for children's health, morbidity and mortality. Prospective cohort study design allows for the identification of exposures that may influence pregnancy outcome and children's health, verification of such exposures by biomarker measurements and notification of any changes in exposure level. MATERIALS AND METHODS: Polish Mother and Child Cohort Study (REPRO_PL) is multicenter prospective cohort study conducted in 8 different regions of Poland. The final cohort is intended to comprise 1300 mother-child pairs to be recruited within 4-year period (2007-2011). The recruitment and all scheduled visits are conducted in maternity units or clinics in the districts included in the study. The women are followed-up 3 times in pregnancy (once in each trimester) and after delivery for the notification of pregnancy outcome. During each visit, detailed questionnaire and biological samples are collected including saliva, urine, hair, maternal blood and cord blood. About 6 weeks postpartum, breast milk from part of the women is collected. The study concentrates on the identification and evaluation of the effects of prenatal environmental exposure on pregnancy outcome and children's health. Specific research hypotheses refer to the role of heavy metals, exposure to polycyclic aromatic hydrocarbons (PAHs) and environmental tobacco smoke (ETS) in the aetiology of small-for-gestational-age (SGA) and preterm delivery (PD). The role of oxidative stress putative mechanism and pregnant women nutritional status will be investigated. Based on questionnaire data, the impact of occupational exposures and stressful situations will be evaluated. RESULTS: The results of the study will become available within the next few years and will help to determine levels of child prenatal exposure in several areas of Poland and its impact on course and outcome of pregnancy.
Authors: Martine Vrijheid; Maribel Casas; Anna Bergström; Amanda Carmichael; Sylvaine Cordier; Merete Eggesbø; Esben Eller; Maria P Fantini; Mariana F Fernández; Ana Fernández-Somoano; Ulrike Gehring; Regina Grazuleviciene; Cynthia Hohmann; Anne M Karvonen; Thomas Keil; Manolis Kogevinas; Gudrun Koppen; Ursula Krämer; Claudia E Kuehni; Per Magnus; Renata Majewska; Anne-Marie Nybo Andersen; Evridiki Patelarou; Maria Skaalum Petersen; Frank H Pierik; Kinga Polanska; Daniela Porta; Lorenzo Richiardi; Ana Cristina Santos; Rémy Slama; Radim J Sram; Carel Thijs; Christina Tischer; Gunnar Toft; Tomáš Trnovec; Stephanie Vandentorren; Tanja G M Vrijkotte; Michael Wilhelm; John Wright; Mark Nieuwenhuijsen Journal: Environ Health Perspect Date: 2011-08-29 Impact factor: 9.031
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Authors: Kinga Polanska; Anna Krol; Pawel Kaluzny; Danuta Ligocka; Karolina Mikolajewska; Seif Shaheen; Robert Walton; Wojciech Hanke Journal: Int J Environ Res Public Health Date: 2016-12-08 Impact factor: 3.390
Authors: Jolanta Gromadzinska; Kinga Polanska; Lucyna Kozlowska; Karolina Mikolajewska; Iwona Stelmach; Joanna Jerzyńska; Włodzimierz Stelmach; Mariusz Grzesiak; Wojciech Hanke; Wojciech Wasowicz Journal: Int J Environ Res Public Health Date: 2018-06-12 Impact factor: 3.390