BACKGROUND: Induced moderate hypothermia (HT) for 72 h has been shown to reduce the combined outcome of death or severe neurodevelopmental disabilities in asphyxiated full-term infants. A pathological amplitude integrated EEG background as early as 3-6 h after birth, has been shown to correlate to poor prognosis. AIM: The aim of this study was to investigate the correlation between amplitude integrated EEG during HT treatment and short-term outcome in asphyxiated full-term infants with moderate/severe hypoxic-ischaemic encephalopathy. METHODS: Between December 2006 and December 2007, 24 infants were treated with moderate HT (33.5 degrees C for 72 h) using a cooling mattress. Motor functions were assessed at 4 and 12 months of age. RESULTS: Of the total birth cohort of 28,837 infants, 26 infants fulfilled the criteria for HT treatment (0.9/1000) of whom 23 was treated with HT and all of these infants had available amplitude integrated EEG data. Normal 1-year outcome was found in 10/15 infants with severely abnormal burst-suppression pattern or worse at 6 h of age. Severe abnormalities were found to be significantly predictive for abnormal outcome after 36 h. CONCLUSION: Among asphyxiated infants treated with HT, only those who had aEEG abnormalities persisting at and beyond 24 h after birth showed poor neurological outcome at 1 year.
BACKGROUND: Induced moderate hypothermia (HT) for 72 h has been shown to reduce the combined outcome of death or severe neurodevelopmental disabilities in asphyxiated full-term infants. A pathological amplitude integrated EEG background as early as 3-6 h after birth, has been shown to correlate to poor prognosis. AIM: The aim of this study was to investigate the correlation between amplitude integrated EEG during HT treatment and short-term outcome in asphyxiated full-term infants with moderate/severe hypoxic-ischaemic encephalopathy. METHODS: Between December 2006 and December 2007, 24 infants were treated with moderate HT (33.5 degrees C for 72 h) using a cooling mattress. Motor functions were assessed at 4 and 12 months of age. RESULTS: Of the total birth cohort of 28,837 infants, 26 infants fulfilled the criteria for HT treatment (0.9/1000) of whom 23 was treated with HT and all of these infants had available amplitude integrated EEG data. Normal 1-year outcome was found in 10/15 infants with severely abnormal burst-suppression pattern or worse at 6 h of age. Severe abnormalities were found to be significantly predictive for abnormal outcome after 36 h. CONCLUSION: Among asphyxiated infants treated with HT, only those who had aEEG abnormalities persisting at and beyond 24 h after birth showed poor neurological outcome at 1 year.
Authors: Renée A Shellhaas; Juhi S Kushwaha; Melissa A Plegue; David T Selewski; John D E Barks Journal: J Child Neurol Date: 2015-02-27 Impact factor: 1.987
Authors: Elizabeth K Sewell; Gilbert Vezina; Taeun Chang; Tammy Tsuchida; Kari Harris; Michelande Ridore; Penny Glass; An N Massaro Journal: Am J Perinatol Date: 2017-09-28 Impact factor: 1.862
Authors: Seetha Shankaran; Athina Pappas; Scott A McDonald; Abbot R Laptook; Rebecca Bara; Richard A Ehrenkranz; Jon E Tyson; Ronald Goldberg; Edward F Donovan; Avroy A Fanaroff; Abhik Das; W Kenneth Poole; Michele Walsh; Rosemary D Higgins; Cherie Welsh; Walid Salhab; Waldemar A Carlo; Brenda Poindexter; Barbara J Stoll; Ronnie Guillet; Neil N Finer; David K Stevenson; Charles R Bauer Journal: Pediatrics Date: 2011-06-13 Impact factor: 7.124
Authors: Renée A Shellhaas; Brian J Thelen; Jayapalli R Bapuraj; Joseph W Burns; Aaron W Swenson; Mary K Christensen; Stephanie A Wiggins; John D E Barks Journal: Neurology Date: 2013-06-14 Impact factor: 9.910
Authors: M Brandon Westover; Mouhsin M Shafi; Shinung Ching; Jessica J Chemali; Patrick L Purdon; Sydney S Cash; Emery N Brown Journal: J Neurosci Methods Date: 2013-07-23 Impact factor: 2.390
Authors: Rosemary D Higgins; Tonse Raju; A David Edwards; Denis V Azzopardi; Carl L Bose; Reese H Clark; Donna M Ferriero; Ronnie Guillet; Alistair J Gunn; Henrik Hagberg; Deborah Hirtz; Terrie E Inder; Susan E Jacobs; Dorothea Jenkins; Sandra Juul; Abbot R Laptook; Jerold F Lucey; Mervyn Maze; Charles Palmer; Luann Papile; Robert H Pfister; Nicola J Robertson; Mary Rutherford; Seetha Shankaran; Faye S Silverstein; Roger F Soll; Marianne Thoresen; William F Walsh Journal: J Pediatr Date: 2011-08-27 Impact factor: 4.406
Authors: Denis Azzopardi; Brenda Strohm; Louise Linsell; Anna Hobson; Edmund Juszczak; Jennifer J Kurinczuk; Peter Brocklehurst; A David Edwards Journal: PLoS One Date: 2012-06-13 Impact factor: 3.240