| Literature DB >> 20050672 |
Hai Xue1, Xiaofan Lu, Purong Zheng, Li Liu, Chunyan Han, Jinping Hu, Zijie Liu, Tao Ma, Yan Li, Lin Wang, Zhiwei Chen, Gang Liu.
Abstract
We herein report a new compound: 10-chloromethyl-11-demethyl-12-oxo-calanolide A (20, EC(50) = 7.4 nM, SI = 1417), which demonstrates a druggable profile with 32.7% oral bioavailability in rat, tolerated oral single dose toxicity in mice, and especially the feature of highly efficient suppression of the wild-type HIV-1 and Y181C mutant HIV-1 at an EC(50) = 7.4 nM and EC(50) = 0.46 nM, respectively.Entities:
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Year: 2010 PMID： 20050672 DOI： 10.1021/jm901653e
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446