| Literature DB >> 20049901 |
Marina Morigi1, Cinzia Rota, Tiziana Montemurro, Elisa Montelatici, Viviana Lo Cicero, Barbara Imberti, Mauro Abbate, Carla Zoja, Paola Cassis, Lorena Longaretti, Paolo Rebulla, Martino Introna, Chiara Capelli, Ariela Benigni, Giuseppe Remuzzi, Lorenza Lazzari.
Abstract
In search for new sources of mesenchymal stem cells (MSCs) for renal repair in acute kidney injury (AKI), we investigated the potential of human cord blood (CB)-MSCs to cure mice with AKI. Infusion of CB-MSCs in immunodeficient mice with cisplatin-induced AKI ameliorated both renal function and tubular cell injury, and prolonged survival. Transplanted CB-MSCs localized in peritubular areas, limited capillary alterations and neutrophil infiltration. Apoptosis reduced and tubular cell proliferation increased by virtue of stem cell capacity to produce growth factors. The reno-protective effect of CB-MSCs was further confirmed by their ability to inhibit oxidative damage and to induce the prosurvival factor Akt in tubular cells. The evidence that CB-MSCs in vitro increased the production of growth factors and inhibited IL-1 beta and TNFalpha synthesis when cocultured with damaged proximal tubular cells indicates a regenerative and anti-inflammatory action of stem cell treatment. Altogether these results highlight the potential of human CB-MSCs as future cell therapy for testing in human AKI.Entities:
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Year: 2010 PMID： 20049901 DOI： 10.1002/stem.293
Source DB: PubMed Journal: Stem Cells ISSN： 1066-5099 Impact factor: 6.277