BACKGROUND: Postoperative intra-abdominal adhesion is a common morbidity after laparotomy. We try to determine whether peritoneal infusion with cold saline may decrease postoperative intra-abdominal adhesion formation. METHODS: Ninety-six male BALB/c mice weighing 25-30 g were randomized into four groups: (I) adhesion model with infusion of 4 degrees C cold saline, (II) adhesion model with infusion of room temperature saline, (III) adhesion model without infusion of saline, and (IV) sham operation without infusion of saline. Adhesion scores, incidence of adhesion, and serum cytokines were measured at postoperative days 1, 3, 7, and 14. RESULTS: Group I had lower adhesion scores than groups II and III (P < 0.0001). IL-6, IL-10, and TNF-alpha were significantly increased in the groups I, II, and III compared to group IV (P < 0.0001). IL-6 in group I was significantly decreased compared to that in group III (P < 0.0004). IL-10 in group I was significantly increased compared to that in groups II (P < 0.0001) and III (P < 0.05). TNF-alpha in group I was significantly decreased compared to that in groups II (P < 0.0004), and III (P < 0.05). CONCLUSION: Peritoneal infusion with cold saline may decrease the degree of postoperative intra-abdominal adhesion formation.
BACKGROUND: Postoperative intra-abdominal adhesion is a common morbidity after laparotomy. We try to determine whether peritoneal infusion with cold saline may decrease postoperative intra-abdominal adhesion formation. METHODS: Ninety-six male BALB/c mice weighing 25-30 g were randomized into four groups: (I) adhesion model with infusion of 4 degrees C cold saline, (II) adhesion model with infusion of room temperature saline, (III) adhesion model without infusion of saline, and (IV) sham operation without infusion of saline. Adhesion scores, incidence of adhesion, and serum cytokines were measured at postoperative days 1, 3, 7, and 14. RESULTS: Group I had lower adhesion scores than groups II and III (P < 0.0001). IL-6, IL-10, and TNF-alpha were significantly increased in the groups I, II, and III compared to group IV (P < 0.0001). IL-6 in group I was significantly decreased compared to that in group III (P < 0.0004). IL-10 in group I was significantly increased compared to that in groups II (P < 0.0001) and III (P < 0.05). TNF-alpha in group I was significantly decreased compared to that in groups II (P < 0.0004), and III (P < 0.05). CONCLUSION: Peritoneal infusion with cold saline may decrease the degree of postoperative intra-abdominal adhesion formation.
Authors: Arin K Greene; Ian P J Alwayn; Vania Nose; Evelyn Flynn; David Sampson; David Zurakowski; Judah Folkman; Mark Puder Journal: Ann Surg Date: 2005-07 Impact factor: 12.969
Authors: Fausto Catena; Salomone Di Saverio; Michael D Kelly; Walter L Biffl; Luca Ansaloni; Vincenzo Mandalà; George C Velmahos; Massimo Sartelli; Gregorio Tugnoli; Massimo Lupo; Stefano Mandalà; Antonio D Pinna; Paul H Sugarbaker; Harry Van Goor; Ernest E Moore; Johannes Jeekel Journal: World J Emerg Surg Date: 2011-01-21 Impact factor: 5.469
Authors: Salomone Di Saverio; Fausto Catena; Federico Coccolini; Marica Galati; Nazareno Smerieri; Walter L Biffl; Luca Ansaloni; Gregorio Tugnoli; George C Velmahos; Massimo Sartelli; Cino Bendinelli; Gustavo Pereira Fraga; Michael D Kelly; Frederick A Moore; Vincenzo Mandalà; Stefano Mandalà; Michele Masetti; Elio Jovine; Antonio D Pinna; Andrew B Peitzman; Ari Leppaniemi; Paul H Sugarbaker; Harry Van Goor; Ernest E Moore; Johannes Jeekel Journal: World J Emerg Surg Date: 2013-10-10 Impact factor: 5.469