Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.

Literature DB >> 20047998

C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.

Klaus Wethmar¹, Valérie Bégay, Jeske J Smink, Katrin Zaragoza, Volker Wiesenthal, Bernd Dörken, Cornelis F Calkhoven, Achim Leutz.

Abstract

Upstream ORFs (uORFs) are translational control elements found predominantly in transcripts of key regulatory genes. No mammalian genetic model exists to experimentally validate the physiological relevance of uORF-regulated translation initiation. We report that mice deficient for the CCAAT/enhancer-binding protein beta (C/EBPbeta) uORF initiation codon fail to initiate translation of the autoantagonistic LIP (liver inhibitory protein) C/EBPbeta isoform. C/EBPbeta(DeltauORF) mice show hyperactivation of acute-phase response genes, persistent repression of E2F-regulated genes, delayed and blunted S-phase entry of hepatocytes after partial hepatectomy, and impaired osteoclast differentiation. These data and the widespread prevalence of uORFs in mammalian transcriptomes suggest a comprehensive role of uORF-regulated translation in (patho)physiology.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20047998 PMCID： PMC2802187 DOI： 10.1101/gad.557910

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

38 in total

1. Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma.

Authors: L Liu; D Dilworth; L Gao; J Monzon; A Summers; N Lassam; D Hogg
Journal: Nat Genet Date: 1999-01 Impact factor: 38.330

Review 2. Stop and go: anti-proliferative and mitogenic functions of the transcription factor C/EBPbeta.

Authors: Thomas Sebastian; Peter F Johnson
Journal: Cell Cycle Date: 2006-05-01 Impact factor: 4.534

3. RNA CUG-binding protein 1 increases translation of 20-kDa isoform of CCAAT/enhancer-binding protein beta by interacting with the alpha and beta subunits of eukaryotic initiation translation factor 2.

Authors: Nikolai A Timchenko; Gou-Li Wang; Lubov T Timchenko
Journal: J Biol Chem Date: 2005-03-23 Impact factor: 5.157

4. MafB negatively regulates RANKL-mediated osteoclast differentiation.

Authors: Kabsun Kim; Jung Ha Kim; Junwon Lee; Hye Mi Jin; Hyun Kook; Kyung Keun Kim; Soo Young Lee; Nacksung Kim
Journal: Blood Date: 2006-12-07 Impact factor: 22.113

5. CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy.

Authors: L E Greenbaum; W Li; D E Cressman; Y Peng; G Ciliberto; V Poli; R Taub
Journal: J Clin Invest Date: 1998-09-01 Impact factor: 14.808

6. C/EBPbeta cooperates with RB:E2F to implement Ras(V12)-induced cellular senescence.

Authors: Thomas Sebastian; Radek Malik; Sara Thomas; Julien Sage; Peter Frederick Johnson
Journal: EMBO J Date: 2005-08-18 Impact factor: 11.598

Review 7. The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control.

Authors: Claus Nerlov
Journal: Trends Cell Biol Date: 2007-07-19 Impact factor: 20.808

Review 8. Translation matters: protein synthesis defects in inherited disease.

Authors: Gert C Scheper; Marjo S van der Knaap; Christopher G Proud
Journal: Nat Rev Genet Date: 2007-07-31 Impact factor: 53.242

9. C/EBPbeta, but not C/EBPalpha, is essential for ductal morphogenesis, lobuloalveolar proliferation, and functional differentiation in the mouse mammary gland.

Authors: T N Seagroves; S Krnacik; B Raught; J Gay; B Burgess-Beusse; G J Darlington; J M Rosen
Journal: Genes Dev Date: 1998-06-15 Impact factor: 11.361

10. uAUG and uORFs in human and rodent 5'untranslated mRNAs.

Authors: Michele Iacono; Flavio Mignone; Graziano Pesole
Journal: Gene Date: 2005-04-11 Impact factor: 3.688

54 in total

1. TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation.

Authors: Alessia Perino; Thijs Willem Hendrik Pols; Mitsunori Nomura; Sokrates Stein; Roberto Pellicciari; Kristina Schoonjans
Journal: J Clin Invest Date: 2014-11-03 Impact factor: 14.808

2. Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBPβ - MafB axis.

Authors: Jeske J Smink; Per-Ulf Tunn; Achim Leutz
Journal: J Mol Med (Berl) Date: 2011-11-10 Impact factor: 4.599

3. CCAAT enhancer-binding proteins have long boney fingers.

Authors: Friedrich C Luft
Journal: J Mol Med (Berl) Date: 2012-01 Impact factor: 4.599

4. Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB.

Authors: Andreas Zankl; Emma L Duncan; Paul J Leo; Graeme R Clark; Evgeny A Glazov; Marie-Claude Addor; Troels Herlin; Chong Ae Kim; Bruno P Leheup; Jim McGill; Steven McTaggart; Stephan Mittas; Anna L Mitchell; Geert R Mortier; Stephen P Robertson; Marie Schroeder; Paulien Terhal; Matthew A Brown
Journal: Am J Hum Genet Date: 2012-03-01 Impact factor: 11.025

5. A proteogenomics approach integrating proteomics and ribosome profiling increases the efficiency of protein identification and enables the discovery of alternative translation start sites.

Authors: Alexander Koch; Daria Gawron; Sandra Steyaert; Elvis Ndah; Jeroen Crappé; Sarah De Keulenaer; Ellen De Meester; Ming Ma; Ben Shen; Kris Gevaert; Wim Van Criekinge; Petra Van Damme; Gerben Menschaert
Journal: Proteomics Date: 2014-10-02 Impact factor: 3.984

Review 6. uORF-mediated translational control: recently elucidated mechanisms and implications in cancer.

Authors: Hung-Hsi Chen; Woan-Yuh Tarn
Journal: RNA Biol Date: 2019-06-24 Impact factor: 4.652

7. An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna.

Authors: Phillip A Dumesic; Daniel F Egan; Philipp Gut; Mei T Tran; Alice Parisi; Nirmalya Chatterjee; Mark Jedrychowski; Margherita Paschini; Lawrence Kazak; Sarah E Wilensky; Florence Dou; Dina Bogoslavski; Jeffrey A Cartier; Norbert Perrimon; Shingo Kajimura; Samir M Parikh; Bruce M Spiegelman
Journal: Cell Metab Date: 2019-05-16 Impact factor: 27.287