Literature DB >> 2004780

Human tryptophan oxygenase localized to 4q31: possible implications for alcoholism and other behavioral disorders.

D E Comings1, D Muhleman, G W Dietz, T Donlon.   

Abstract

A human tryptophan oxygenase clone was isolated by screening a liver cDNA library with a rat tryptophan oxygenase cDNA clone. Analysis showed extensive homology between the rat and the human DNA and protein sequences. The combined use of cell hybrids and in situ hydridization indicated that human tryptophan oxygenase was localized to chromosome band 4q31. The tryptophan oxygenase gene may be important in some human behavior disorders, especially those associated with abnormalities of serotonin metabolism.

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Year:  1991        PMID： 2004780     DOI： 10.1016/0888-7543(91)90257-f

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  2 in total

1.  Seven loci on human chromosome 4 map onto sheep chromosome 6: a proposal to restore the original nomenclature of this sheep chromosome.

Authors:  T E Broad; D J Burkin; L M Cambridge; D W Maher; P E Lewis; H A Ansari; P D Pearce; C Jones
Journal:  Mamm Genome       Date:  1994-07       Impact factor: 2.957

2.  Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classes.

Authors:  K Edman; W Maret
Journal:  Hum Genet       Date:  1992-12       Impact factor: 4.132
  2 in total

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