OBJECTIVES: Although autonomic dysfunction was found in advanced Huntington's disease (HD) patients it is not clear whether there is autonomic dysfunction in presymptomatic and early symptomatic HD. MATERIAL & METHODS: Different cardiovascular autonomic tests were performed in 14 presymptomatic HD mutation carriers (PHD), 11 early symptomatic HD patients (EHD) and in 25 sex and age matched controls. RESULTS: We found attenuated response to simple mental arithmetic test (relative heart rate in PHD and EHD was 10% lower than in controls; diastolic pressure was 10.6% lower in EHD than in controls; P < 0.05) and exaggerated response to the late phase of cold pressor test (relative heart rate was 10% higher in PHD and 7% higher in EHD than in controls; P < 0.05). The rest of the cardiovascular autonomic tests did not reveal significant differences between patients and controls. CONCLUSIONS: Our results suggest that subtle autonomic dysfunction occurs even in PHD and EHD.
OBJECTIVES: Although autonomic dysfunction was found in advanced Huntington's disease (HD) patients it is not clear whether there is autonomic dysfunction in presymptomatic and early symptomatic HD. MATERIAL & METHODS: Different cardiovascular autonomic tests were performed in 14 presymptomatic HD mutation carriers (PHD), 11 early symptomatic HDpatients (EHD) and in 25 sex and age matched controls. RESULTS: We found attenuated response to simple mental arithmetic test (relative heart rate in PHD and EHD was 10% lower than in controls; diastolic pressure was 10.6% lower in EHD than in controls; P < 0.05) and exaggerated response to the late phase of cold pressor test (relative heart rate was 10% higher in PHD and 7% higher in EHD than in controls; P < 0.05). The rest of the cardiovascular autonomic tests did not reveal significant differences between patients and controls. CONCLUSIONS: Our results suggest that subtle autonomic dysfunction occurs even in PHD and EHD.
Authors: Takashi Kudo; Analyne Schroeder; Dawn H Loh; Dika Kuljis; Maria C Jordan; Kenneth P Roos; Christopher S Colwell Journal: Exp Neurol Date: 2010-12-22 Impact factor: 5.330
Authors: Benjamin Smarr; Tamara Cutler; Dawn H Loh; Takashi Kudo; Dika Kuljis; Lance Kriegsfeld; Cristina A Ghiani; Christopher S Colwell Journal: J Neurosci Res Date: 2019-07-29 Impact factor: 4.164
Authors: Kathleen J Griffioen; Ruiqian Wan; Tashalee R Brown; Eitan Okun; Simonetta Camandola; Mohamed R Mughal; Terry M Phillips; Mark P Mattson Journal: Neurobiol Aging Date: 2011-12-31 Impact factor: 4.673
Authors: Nigel I Wood; Stephen J Sawiak; Guido Buonincontri; Youguo Niu; Andrew D Kane; T Adrian Carpenter; Dino A Giussani; A Jennifer Morton Journal: J Huntingtons Dis Date: 2012
Authors: Guido Buonincontri; Nigel I Wood; Simon G Puttick; Alex O Ward; T Adrian Carpenter; Stephen J Sawiak; A Jennifer Morton Journal: J Huntingtons Dis Date: 2014