Literature DB >> 2004731

Mammalian ciliary-body epithelial cells in culture produce transforming growth factor-beta.

H Helbig1, K L Kittredge, M Coca-Prados, J Davis, A G Palestine, R B Nussenblatt.   

Abstract

Transforming growth factor-beta (TGF-beta) has recently been found in the aqueous humor. The present study was initiated to test whether the ciliary-body epithelium, the site of aqueous humor formation, is capable of producing TGF-beta. Human, rat and bovine ciliary epithelial cells were grown in tissue culture and their supernatants were tested for TGF-beta using a bioassay. After acid activation of the samples, TGF-beta activity was found in the supernatants of all three mammalian ciliary epithelial cells. Most of this activity could be blocked by a neutralizing antibody against TGF-beta type 2. Native supernatants did not contain detectable TGF-beta activity. Thus, the ciliary epithelium is capable of producing the inactive form of TGF-beta (mainly type 2) and may be a source of TGF-beta in the aqueous humor.

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Year:  1991        PMID： 2004731     DOI： 10.1007/bf00172268

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN： 0721-832X            Impact factor:   3.117


  12 in total

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Authors:  H Helbig; C Korbmacher; J Wohlfarth; M Coca-Prados; M Wiederholt
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Authors:  A B Roberts; M B Sporn
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Review 5.  Aqueous humor factors and their effect on the immune response in the anterior chamber.

Authors:  J W Streilein; S W Cousins
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6.  Expression of Na,K-ATPase alpha subunit isoforms in the human ciliary body and cultured ciliary epithelial cells.

Authors:  P Martin-Vasallo; S Ghosh; M Coca-Prados
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Journal:  Arch Ophthalmol       Date:  1989-04

8.  Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye.

Authors:  T B Connor; A B Roberts; M B Sporn; D Danielpour; L L Dart; R G Michels; S de Bustros; C Enger; H Kato; M Lansing
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9.  Comparison of the biological actions of TGF beta-1 and TGF beta-2: differential activity in endothelial cells.

Authors:  J C Jennings; S Mohan; T A Linkhart; R Widstrom; D J Baylink
Journal:  J Cell Physiol       Date:  1988-10       Impact factor: 6.384

10.  Ciliary epithelia of the mammalian eye in cultured explants.

Authors:  K Kondo; M Coca-Prados; M Sears
Journal:  Cell Tissue Res       Date:  1983       Impact factor: 5.249
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