BACKGROUND: Although the associations between grilled (broiled) or barbecued meats or fish intake and stomach cancer risk have been investigated, the evidence implicating heterocyclic amine (HCA) intake as a cause of stomach cancer is limited. We conducted a case-control study to investigate the association between HCA intake and stomach cancer risk. We also investigated the possible effect of genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on stomach cancer. METHODS: HCA exposure data were assessed using a self-administered food-frequency questionnaire, and estimated HCA intake was verified by measuring 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) values in human hair. A total of 149 cases and 296 controls were included in the analyses. Odds ratios (ORs) were calculated, using conditional logistic regression analysis, to compare intake levels between the first and third tertiles. RESULTS: Results showed no statistically significant increase in the risk of stomach cancer with respect to total HCA intake (OR, 1.11; 95% confidence interval [CI], 0.36, 3.49), or with respect to the intake of individual HCAs; namely, PhIP, 2-amino-3, 4-dimethylimidazo[4,5-f]quinoline (MeIQ), and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). Genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 did not influence the association of HCA intake with stomach cancer. CONCLUSION: In the present study, with a limited sample size of subjects with low HCA exposure, no association was found between HCA intake and stomach cancer, nor was there any evidence of any influence by genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on the risk of stomach cancer.
BACKGROUND: Although the associations between grilled (broiled) or barbecued meats or fish intake and stomach cancer risk have been investigated, the evidence implicating heterocyclic amine (HCA) intake as a cause of stomach cancer is limited. We conducted a case-control study to investigate the association between HCA intake and stomach cancer risk. We also investigated the possible effect of genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on stomach cancer. METHODS:HCA exposure data were assessed using a self-administered food-frequency questionnaire, and estimated HCA intake was verified by measuring 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) values in human hair. A total of 149 cases and 296 controls were included in the analyses. Odds ratios (ORs) were calculated, using conditional logistic regression analysis, to compare intake levels between the first and third tertiles. RESULTS: Results showed no statistically significant increase in the risk of stomach cancer with respect to total HCA intake (OR, 1.11; 95% confidence interval [CI], 0.36, 3.49), or with respect to the intake of individual HCAs; namely, PhIP, 2-amino-3, 4-dimethylimidazo[4,5-f]quinoline (MeIQ), and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). Genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 did not influence the association of HCA intake with stomach cancer. CONCLUSION: In the present study, with a limited sample size of subjects with low HCA exposure, no association was found between HCA intake and stomach cancer, nor was there any evidence of any influence by genetic polymorphisms of NAT2, CYP1A1, and CYP1A2 on the risk of stomach cancer.
Authors: Susan Nowell; Brian Coles; Rashmi Sinha; Stewart MacLeod; D Luke Ratnasinghe; Craig Stotts; Fred F Kadlubar; Christine B Ambrosone; Nicholas P Lang Journal: Mutat Res Date: 2002-09-30 Impact factor: 2.433
Authors: Antonio Agudo; Núria Sala; Guillem Pera; Gabriel Capellá; Antonio Berenguer; Nadia García; Domenico Palli; Heiner Boeing; Giuseppe Del Giudice; Calogero Saieva; Fatima Carneiro; Franco Berrino; Carlotta Sacerdote; Rosario Tumino; Salvatore Panico; Göran Berglund; Henrik Simán; Roger Stenling; Göran Hallmans; Carmen Martínez; Roberto Bilbao; Aurelio Barricarte; Carmen Navarro; José R Quirós; Naomi Allen; Tim Key; Sheila Bingham; Kay-Tee Khaw; Jakob Linseisen; Gabriele Nagel; Kim Overvad; Anne Tjonneland; Anja Olsen; H Bas Bueno-de-Mesquita; Hendriek C Boshuizen; Petra H Peeters; Mattijs E Numans; Françoise Clavel-Chapelon; Marie-Christine Boutron-Ruault; Antonia Trichopoulou; Eiliv Lund; Johan Offerhaus; Mazda Jenab; Pietro Ferrari; Teresa Norat; Elio Riboli; Carlos A González Journal: Cancer Epidemiol Biomarkers Prev Date: 2006-12 Impact factor: 4.254
Authors: Hae-Jeung Lee; Kana Wu; David G Cox; David Hunter; Susan E Hankinson; Walter C Willett; Rashmi Sinha; Eunyoung Cho Journal: Nutr Cancer Date: 2013-10-07 Impact factor: 2.900