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Literature DB >> 2004696

Hemin-binding property of Porphyromonas gingivalis outer membranes.

Abstract

The present study indicates that the outer membranes of Porphyromonas gingivalis have a high affinity for hemin, an essential growth factor for this suspected periodontal pathogen. The hemin-binding property appears to be mediated by the lipopolysaccharides, particularly the lipid A region. It is suggested that this binding mechanism may be important for the growth and establishment of P. gingivalis in environments with a low hemin content such as periodontal pockets.

Entities: Chemical Species

Mesh：

Substances：
Growth Substances
Hemin

Year: 1991 PMID： 2004696 DOI： 10.1016/0378-1097(91)90011-x

Source DB: PubMed Journal: FEMS Microbiol Lett ISSN： 0378-1097 Impact factor: 2.742

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Cited

12 in total

Review 1. Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens.

Authors: Laura L Anzaldi; Eric P Skaar
Journal: Infect Immun Date: 2010-08-02 Impact factor: 3.441

2. Binding of hemoglobin to the envelope of Porphyromonas gingivalis and isolation of the hemoglobin-binding protein.

Authors: S Fujimura; Y Shibata; K Hirai; T Nakamura
Journal: Infect Immun Date: 1996-06 Impact factor: 3.441

3. The periodontopathogen Porphyromonas gingivalis binds iron protoporphyrin IX in the mu-oxo dimeric form: an oxidative buffer and possible pathogenic mechanism.

Authors: J W Smalley; J Silver; P J Marsh; A J Birss
Journal: Biochem J Date: 1998-05-01 Impact factor: 3.857

4. Hemin-induced modifications of the antigenicity and hemin-binding capacity of Porphyromonas gingivalis lipopolysaccharide.

Authors: C W Cutler; P I Eke; C A Genco; T E Van Dyke; R R Arnold
Journal: Infect Immun Date: 1996-06 Impact factor: 3.441

10. Characterization of a Tn4351-generated hemin uptake mutant of Porphyromonas gingivalis: evidence for the coordinate regulation of virulence factors by hemin.

Authors: C A Genco; W Simpson; R Y Forng; M Egal; B M Odusanya
Journal: Infect Immun Date: 1995-07 Impact factor: 3.441

Hemin-binding property of Porphyromonas gingivalis outer membranes.

Review 1. Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens.

2. Binding of hemoglobin to the envelope of Porphyromonas gingivalis and isolation of the hemoglobin-binding protein.

3. The periodontopathogen Porphyromonas gingivalis binds iron protoporphyrin IX in the mu-oxo dimeric form: an oxidative buffer and possible pathogenic mechanism.

4. Hemin-induced modifications of the antigenicity and hemin-binding capacity of Porphyromonas gingivalis lipopolysaccharide.

5. Utilization of hemin and hemoglobin by Vibrio vulnificus biotype 2.

6. Detection and comparison of specific hemin binding by Porphyromonas gingivalis and Prevotella intermedia.

7. Hemin uptake in Porphyromonas gingivalis: Omp26 is a hemin-binding surface protein.

8. Lipopolysaccharides of Actinobacillus pleuropneumoniae bind pig hemoglobin.

9. Characterization of lactoferrin binding by Aeromonas hydrophila.

10. Characterization of a Tn4351-generated hemin uptake mutant of Porphyromonas gingivalis: evidence for the coordinate regulation of virulence factors by hemin.