OBJECTIVE: We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment. METHODS: A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (+/-19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T, rs2005976 G/A, rs760761 C/T and rs2619522 A/C). RESULTS: There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors. CONCLUSION: Although the small number of subjects is an important limitation in our study, DTNBP1 does not seem to be involved in acute antimanic efficacy.
OBJECTIVE: We previously reported an association between dysbindin gene (DTNBP1) variants and bipolar I disorder (BID). This paper expands upon previous findings suggesting that DTNBP1 variants may play a role in the response to acute mood stabilizer treatment. METHODS: A total of 45 BID patients were treated with antimanic agents (lithium, valproate, or carbamazepine) for an average of 36.52 (+/-19.87) days. After treatment, the patients were evaluated using the Clinical Global Impression (CGI) scale and the Young Mania Rating Scale (YMRS) and genotyped for their DTNBP1 variants (rs3213207 A/G, rs1011313 C/T, rs2005976 G/A, rs760761 C/T and rs2619522 A/C). RESULTS: There was no association between the variants investigated and response to mood stabilizer treatment, even after considering possible stratification factors. CONCLUSION: Although the small number of subjects is an important limitation in our study, DTNBP1 does not seem to be involved in acute antimanic efficacy.
Authors: Sibylle G Schwab; Michael Knapp; Stephanie Mondabon; Joachim Hallmayer; Margitta Borrmann-Hassenbach; Margot Albus; Bernard Lerer; Marcella Rietschel; Matyas Trixler; Wolfgang Maier; Dieter B Wildenauer Journal: Am J Hum Genet Date: 2002-12-09 Impact factor: 11.025
Authors: Robert R Althoff; Stephen V Faraone; David C Rettew; Christopher P Morley; James J Hudziak Journal: Bipolar Disord Date: 2005-12 Impact factor: 6.744
Authors: Martin Alda; Paul Grof; Guy A Rouleau; Gustavo Turecki; L Trevor Young Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2005-07 Impact factor: 5.067
Authors: Jubao Duan; Maria Martinez; Alan R Sanders; Cuiping Hou; Gregory J Burrell; Aaron J Krasner; Daniel B Schwartz; Pablo V Gejman Journal: Hum Hered Date: 2007-05-02 Impact factor: 0.444