| Literature DB >> 20045978 |
Meng-Yuan Jiang1, Ling Zhang, Ze-Jun Dong, Zhu-Liang Yang, Ying Leng, Ji-Kai Liu.
Abstract
Three new metabolites, vibralactones D-F (1-3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of 1 was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1-3 were assigned using a modified Mosher's method. Compound 1 showed weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 microM (human HSD1), 295.2 microM (mouse HSD1), and 87.1 microM (human HSD2).Entities:
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Year: 2010 PMID: 20045978 DOI: 10.1248/cpb.58.113
Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN: 0009-2363 Impact factor: 1.645