Literature DB >> 200458

Lead potentiation of endotoxin lethality in rats: lack of effect of kininase inhibition.

S L Gartner.   

Abstract

Although lead and SQ20881 are potent in vitro inhibitors of kininase II activity, SQ20881 does not alter the sensitivity of rats to endotoxin. These results indicate that marked changes in plasma kininase activity do not contribute to endotoxin morbidity and that kininase inhibition is not the mechanism whereby lead ions sensitize rats to endotoxin.

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Year:  1977        PMID： 200458     DOI： 10.1007/bf01918811

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

Review 2.  Angiotensin-converting enzyme and the regulation of vasoactive peptides.

Authors:  R L Soffer
Journal:  Annu Rev Biochem       Date:  1976       Impact factor: 23.643

3.  Inhibition by SQ 20881 of vasopressor response to angiotensin I in conscious animals.

Authors:  A Bianchi; D B Evans; M Cobb; M T Peschka; T R Schaeffer; R J Laffan
Journal:  Eur J Pharmacol       Date:  1973-07       Impact factor: 4.432

4.  Structural requirements for substrates and inhibitors of angiotensin I-converting enzyme in vivo and vitro.

Authors:  S Oparil; T Koerner; J K O'Donoghue
Journal:  Circ Res       Date:  1974-01       Impact factor: 17.367

5.  Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung.

Authors:  D W Cushman; H S Cheung
Journal:  Biochem Pharmacol       Date:  1971-07       Impact factor: 5.858

6.  Angiotensin I converting enzyme and kininase.

Authors:  E Ueda; T Kokubu; H Akutsu; T Ito
Journal:  Jpn Circ J       Date:  1972-06

7.  Kinetics of the plasma and lung angiotensin I converting enzymes.

Authors:  C G Huggins; R J Corcoran; J S Gordon; H W Henry; J P John
Journal:  Circ Res       Date:  1970-07       Impact factor: 17.367

8.  Effect of lead acetate on the susceptibility of rats to bacterial endotoxins.

Authors:  H Selye; B Tuchweber; L Bertók
Journal:  J Bacteriol       Date:  1966-02       Impact factor: 3.490
  8 in total

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