| Literature DB >> 20045697 |
Jing Yang1, Yuan Gu, Yaping Yang, Junfei Wei, Shaohua Wang, Shijuan Cui, Jin Pan, Qiang Li, Xinping Zhu.
Abstract
Our previous studies showed that immunization with recombinant paramyosin from Trichinella spiralis (rTs-Pmy) formulated with Freund's adjuvant significantly reduced larval burden in mice after T. spiralis larval challenge. Since Freund's adjuvant is toxic and not a suitable adjuvant for clinical vaccine trials, we evaluated the ability of the adjuvants Montanide ISA206 and ISA720 to stimulate immune responses during rTs-Pmy immunization and to enhance protective immunity. The results revealed that immunization of BALB/c mice with rTs-Pmy formulated with either ISA206 or ISA720 triggered Th1 and Th2 immune responses similar to those produced by the conventional Freund's adjuvant formulation and also provided a similar level of protection against T. spiralis larval challenge. This indicates that the recombinant Ts-Pmy formulated with Montanide ISA206 or ISA720 may be an effective and safety vaccine strategy for trichinellosis. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20045697 DOI： 10.1016/j.exppara.2009.12.010
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011