K G Lalitha1, M G Sethuraman. 1. Department of Pharmaceutical Chemistry, Ultra College of Pharmacy, Madurai 625 020, Tamil Nadu, India.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally the aqueous extracts of dried roots of the plant Ecbolium viride are used for menorrhagia, rheumatism and jaundice. AIM OF THE STUDY: The aim was to evaluate the anti-inflammatory activity of Ecbolium viride extract in an in vivo model. MATERIALS AND METHODS: The ethyl acetate fraction of Ecbolium viride root extract was prepared and administered orally to rats. The anti-inflammatory activity of Ecbolium viride was determined by carrageenan-induced paw edema and cotton pellet granuloma models. RESULTS: Oral administration of Ecbolium viride extract reduced inflammation significantly (P<0.01) in both the carageenan paw edema and the cotton pellet granuloma models. CONCLUSIONS: The results of the study supported the traditional use of Ecbolium viride in the treatment for inflammatory disease. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
ETHNOPHARMACOLOGICAL RELEVANCE: Traditionally the aqueous extracts of dried roots of the plant Ecbolium viride are used for menorrhagia, rheumatism and jaundice. AIM OF THE STUDY: The aim was to evaluate the anti-inflammatory activity of Ecbolium viride extract in an in vivo model. MATERIALS AND METHODS: The ethyl acetate fraction of Ecbolium viride root extract was prepared and administered orally to rats. The anti-inflammatory activity of Ecbolium viride was determined by carrageenan-induced paw edema and cotton pellet granuloma models. RESULTS: Oral administration of Ecbolium viride extract reduced inflammation significantly (P<0.01) in both the carageenan paw edema and the cotton pellet granuloma models. CONCLUSIONS: The results of the study supported the traditional use of Ecbolium viride in the treatment for inflammatory disease. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: W D Ratnasooriya; J R A C Jayakody; S M Handunnetti; C D T Ratnasooriya; K R Weerasekera Journal: Indian J Pharm Sci Date: 2015 Sep-Oct Impact factor: 0.975