| Literature DB >> 20045339 |
Daniela Rossi1, Mariangela Urbano, Alice Pedrali, Massimo Serra, Daniele Zampieri, Maria Grazia Mamolo, Christian Laggner, Caterina Zanette, Chiara Florio, Dirk Schepmann, Bernard Wuensch, Ornella Azzolina, Simona Collina.
Abstract
In order to investigate the molecular features involved in sigma receptors (sigma-Rs) binding, new compounds based on arylalkylaminoalcoholic, arylalkenyl- and arylalkylaminic scaffolds were synthesized and their affinity towards sigma(1)- and sigma(2)-Rs subtypes was evaluated. The most promising compounds were also screened for their affinity at micro-opioid, delta-opioid and kappa-opioid receptors. Biological results are herein presented and discussed. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Mesh：
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Year: 2009 PMID： 20045339 DOI： 10.1016/j.bmc.2009.12.039
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641