Literature DB >> 20045224

6-Substituted 2-(N-trifluoroacetylamino)imidazopyridines induce cell cycle arrest and apoptosis in SK-LU-1 human cancer cell line.

Miguel Angel Martínez-Urbina1, Alejandro Zentella, Miguel Angel Vilchis-Reyes, Angel Guzmán, Omar Vargas, María Teresa Ramírez Apan, José Luis Ventura Gallegos, Eduardo Díaz.   

Abstract

A series of 6-substituted 2-(N-trifluoroacetylamino)imidazopyridines have been synthesized and their bioactivities were evaluated. Compounds 6a, 6c, and 11a were the most active compounds with modest cytotoxic activity against six human cancer cell lines U251 (glioma), PC-3 (prostate), K-562 (leukemia), HCT-15 (colon), MCF7 (breast) and SK-LU-1 (lung). The cell cycle analysis showed that compounds 6a, 6c, and 11a induce a G2/M phase cell cycle arrest on SK-LU-1 cell line where inhibition of CDK-1 and CDK-2 may be implicated. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

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Year:  2009        PMID： 20045224     DOI： 10.1016/j.ejmech.2009.11.049

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

Review 1.  Cyclin-dependent kinase inhibitors and the treatment of gastrointestinal cancers.

Authors:  Sameh Mikhail; Christopher Albanese; Michael J Pishvaian
Journal:  Am J Pathol       Date:  2015-03-05       Impact factor: 4.307

2.  Electro-organic synthesis of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one via a multicomponent reaction.

Authors:  Mohammad Reza Asghariganjeh; Ali Asghar Mohammadi; Elham Tahanpesar; Ayeh Rayatzadeh; Somayeh Makarem
Journal:  Mol Divers       Date:  2020-01-09       Impact factor: 2.943

3.  A One Pot Synthesis of Novel Bioactive Tri-Substitute-Condensed-Imidazopyridines that Targets Snake Venom Phospholipase A2.

Authors:  Nirvanappa C Anilkumar; Mahalingam S Sundaram; Chakrabhavi Dhananjaya Mohan; Shobith Rangappa; Krishna C Bulusu; Julian E Fuchs; Kesturu S Girish; Andreas Bender; Kanchugarakoppal S Rangappa
Journal:  PLoS One       Date:  2015-07-21       Impact factor: 3.240

4.  Synthesis, biological evaluation and molecular docking studies of 6-(4-nitrophenoxy)-1H-imidazo[4,5-b]pyridine derivatives as novel antitubercular agents: future DprE1 inhibitors.

Authors:  Jineetkumar Gawad; Chandrakant Bonde
Journal:  Chem Cent J       Date:  2018-12-19       Impact factor: 4.215

5.  Crystal structure, Hirshfeld surface analysis and DFT studies of 6-bromo-3-(12-bromo-dodec-yl)-2-(4-nitro-phen-yl)-4H-imidazo[4,5-b]pyridine.

Authors:  Zainab Jabri; Karim Jarmoni; Tuncer Hökelek; Joel T Mague; Safia Sabir; Youssef Kandri Rodi; Khalid Misbahi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2020-04-21

6.  A Novel Imidazopyridine Derivative Exerts Anticancer Activity by Inducing Mitochondrial Pathway-Mediated Apoptosis.

Authors:  Juanli Wang; Hong Wu; Guiting Song; Donglin Yang; Jiuhong Huang; Xiaofang Yao; Hongxia Qin; ZhongZhu Chen; Zhigang Xu; Chuan Xu
Journal:  Biomed Res Int       Date:  2020-08-25       Impact factor: 3.411

Review 7.  A Review of the Recent Developments of Molecular Hybrids Targeting Tubulin Polymerization.

Authors:  Oluwakemi Ebenezer; Michael Shapi; Jack A Tuszynski
Journal:  Int J Mol Sci       Date:  2022-04-04       Impact factor: 5.923
  7 in total

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