| Literature DB >> 20044950 |
Byung Ryong Lee1, So Young Kim, Dae Won Kim, Jae Jin An, Ha Yong Song, Ki Yeon Yoo, Tae Cheon Kang, Moo Ho Won, Kwang Jae Lee, Kwang Hee Kim, Jin Ho Joo, Hun Ju Ham, Jang Hyun Hur, Sung Woo Cho, Kyu Hyung Han, Kil Soo Lee, Jinseu Park, Soo Young Choi, Won Sik Eum.
Abstract
The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach to the treatment of various diseases, including inflammation and cancer. In this study, we examined the effects of the Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced nitric oxide (NO) and cyclooxygenase-2 (COX-2) expression in murine macrophage Raw 264.7 cells as well as 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema in mice. The polysaccharide significantly inhibited (P 0.01) LPS-induced iNOS and COX-2 expression levels in the cells. Furthermore, topical application of polysaccharide resulted in markedly inhibited (P 0.01) TPA-induced ear edema in mice. These results suggest that this polysaccharide may be used for NO- and COX-2-related disorders such as inflammation and cancer.Entities:
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Year: 2009 PMID： 20044950 DOI： 10.5483/bmbrep.2009.42.12.794
Source DB: PubMed Journal: BMB Rep ISSN： 1976-6696 Impact factor: 4.778