Literature DB >> 2004418

Oct-3 is a maternal factor required for the first mouse embryonic division.

M H Rosner1, R J De Santo, H Arnheiter, L M Staudt.   

Abstract

Oct-3 is a POU domain transcription factor that binds the octamer DNA motif and is present in mouse oocytes before and after fertilization. When fertilized oocytes were injected with antisense Oct-3 oligonucleotides or double-stranded DNA containing the octamer motif, embryonic DNA synthesis was inhibited and the embryos were arrested at the one-cell stage. In vitro synthesized Oct-3 mRNA rescued the developmental block induced by antisense Oct-3 oligonucleotide. We conclude that maternally inherited Oct-3 is required for DNA replication and division of the one-cell embryo.

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Year:  1991        PMID： 2004418     DOI： 10.1016/0092-8674(91)90265-z

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  14 in total

1.  Specificity of antisense oligonucleotides in vivo.

Authors:  T M Woolf; D A Melton; C G Jennings
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

2.  Epigenetic Interactions and Gene Expression in Peri-Implantation Mouse Embryo Development.

Authors:  Jean J Latimer; Roger A Pedersen
Journal:  Mod Cell Biol       Date:  1993

3.  Compilation of vertebrate-encoded transcription factors.

Authors:  S Faisst; S Meyer
Journal:  Nucleic Acids Res       Date:  1992-01-11       Impact factor: 16.971

4.  Recognition of the CDEI motif GTCACATG by mouse nuclear proteins and interference with the early development of the mouse embryo.

Authors:  A Blangy; P Léopold; F Vidal; M Rassoulzadegan; F Cuzin
Journal:  Nucleic Acids Res       Date:  1991-12       Impact factor: 16.971

5.  Stringent integrity requirements for both trans-activation and DNA-binding in a trans-activator, Oct3.

Authors:  M Imagawa; A Miyamoto; M Shirakawa; H Hamada; M Muramatsu
Journal:  Nucleic Acids Res       Date:  1991-08-25       Impact factor: 16.971

6.  Regulation of DNA replication in vitro by the transcriptional activation domain of GAL4-VP16.

Authors:  L Z Cheng; J L Workman; R E Kingston; T J Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-15       Impact factor: 11.205

7.  Functional analysis of defined mutations in the immunoglobulin heavy-chain enhancer in transgenic mice.

Authors:  A Annweiler; U Müller; T Wirth
Journal:  Nucleic Acids Res       Date:  1992-04-11       Impact factor: 16.971

8.  The maternal CCAAT box transcription factor which controls GATA-2 expression is novel and developmentally regulated and contains a double-stranded-RNA-binding subunit.

Authors:  R L Orford; C Robinson; J M Haydon; R K Patient; M J Guille
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272

9.  Sequential expression of multiple POU proteins during amphibian early development.

Authors:  C S Hinkley; J F Martin; D Leibham; M Perry
Journal:  Mol Cell Biol       Date:  1992-02       Impact factor: 4.272

10.  dOct2, a Drosophila Oct transcription factor that functions in yeast.

Authors:  K Prakash; X D Fang; D Engelberg; A Behal; C S Parker
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205
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