E H Yeung1, F B Hu, C G Solomon, L Chen, G M Louis, E Schisterman, W C Willett, C Zhang. 1. Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, 7B03, Bethesda, MD 20892, USA. yeungedw@mail.nih.gov
Abstract
AIMS/HYPOTHESIS: We prospectively determined the risk of gestational diabetes mellitus in association with life-course weight characteristics and adult abdominal adiposity. METHODS: We investigated the joint and independent impact of birthweight, childhood size by somatotypes, adolescent and adult BMI, and abdominal adiposity on gestational diabetes mellitus risk among the 21,647 women in the Nurses' Health Study II who reported a singleton pregnancy between 1989 and 2001. A total of 1,386 incident cases of gestational diabetes mellitus were reported. Relative risk was estimated by pooled logistic regression adjusting for age, prematurity, race, smoking status, parental history of diabetes, age of first birth, parity and physical activity. RESULTS: Birthweight was inversely associated with gestational diabetes mellitus risk (p = 0.02 for trend). Childhood somatotypes at ages 5 and 10 years were not associated with risk. U-shaped associations were found for BMI at age 18 years and somatotype at age 20 years. Weight gain between adolescence and adulthood, pre-gravid BMI and abdominal adiposity were positively associated with risk (p < 0.01 for all trends). Multivariate adjusted RRs for gestational diabetes from lowest to highest quintile of WHR were 1.00, 1.50, 1.51, 2.03, 2.12 (p = 0.0003 for trend). Lower birthweight (<7 lb) without adulthood overweight (BMI > 25 kg/m(2)) was associated with a 20% increased risk (95% CI 1.02-1.41). However, adulthood overweight alone was related to a 2.36 times greater risk (95% CI 2.12-3.77). CONCLUSIONS/ INTERPRETATION: Although lower birthweight is an independent risk factor for gestational diabetes mellitus, weight gain since early adulthood, and overall and central obesity in adulthood were more strongly associated with elevated risk of the condition independently of other known risk factors.
AIMS/HYPOTHESIS: We prospectively determined the risk of gestational diabetes mellitus in association with life-course weight characteristics and adult abdominal adiposity. METHODS: We investigated the joint and independent impact of birthweight, childhood size by somatotypes, adolescent and adult BMI, and abdominal adiposity on gestational diabetes mellitus risk among the 21,647 women in the Nurses' Health Study II who reported a singleton pregnancy between 1989 and 2001. A total of 1,386 incident cases of gestational diabetes mellitus were reported. Relative risk was estimated by pooled logistic regression adjusting for age, prematurity, race, smoking status, parental history of diabetes, age of first birth, parity and physical activity. RESULTS: Birthweight was inversely associated with gestational diabetes mellitus risk (p = 0.02 for trend). Childhood somatotypes at ages 5 and 10 years were not associated with risk. U-shaped associations were found for BMI at age 18 years and somatotype at age 20 years. Weight gain between adolescence and adulthood, pre-gravid BMI and abdominal adiposity were positively associated with risk (p < 0.01 for all trends). Multivariate adjusted RRs for gestational diabetes from lowest to highest quintile of WHR were 1.00, 1.50, 1.51, 2.03, 2.12 (p = 0.0003 for trend). Lower birthweight (<7 lb) without adulthood overweight (BMI > 25 kg/m(2)) was associated with a 20% increased risk (95% CI 1.02-1.41). However, adulthood overweight alone was related to a 2.36 times greater risk (95% CI 2.12-3.77). CONCLUSIONS/ INTERPRETATION: Although lower birthweight is an independent risk factor for gestational diabetes mellitus, weight gain since early adulthood, and overall and central obesity in adulthood were more strongly associated with elevated risk of the condition independently of other known risk factors.
Authors: Alison E Field; Debra L Franko; Ruth H Striegel-Moore; George B Schreiber; Patricia B Crawford; Stephen R Daniels Journal: Obes Res Date: 2004-07
Authors: C G Solomon; W C Willett; J Rich-Edwards; D J Hunter; M J Stampfer; G A Colditz; J E Manson Journal: Diabetes Care Date: 1996-01 Impact factor: 19.112
Authors: K K Ong; C J Petry; P M Emmett; M S Sandhu; W Kiess; C N Hales; A R Ness; D B Dunger Journal: Diabetologia Date: 2004-05-20 Impact factor: 10.122
Authors: Rachel M Freathy; Amanda J Bennett; Susan M Ring; Beverley Shields; Christopher J Groves; Nicholas J Timpson; Michael N Weedon; Eleftheria Zeggini; Cecilia M Lindgren; Hana Lango; John R B Perry; Anneli Pouta; Aimo Ruokonen; Elina Hyppönen; Chris Power; Paul Elliott; David P Strachan; Marjo-Riitta Järvelin; George Davey Smith; Mark I McCarthy; Timothy M Frayling; Andrew T Hattersley Journal: Diabetes Date: 2009-02-19 Impact factor: 9.461
Authors: Mary Lou Thompson; Cande V Ananth; Vincent W V Jaddoe; Raymond S Miller; Michelle A Williams Journal: Paediatr Perinat Epidemiol Date: 2014-05-19 Impact factor: 3.980
Authors: Teresa Janevic; Jennifer Zeitlin; Natalia Egorova; Amy Balbierz; Elizabeth A Howell Journal: Ann Epidemiol Date: 2018-02-15 Impact factor: 3.797
Authors: Sara E Schaefer; Eva Erber; Janel P Trzaskos; Cindy Roache; Geraldine Osborne; Sangita Sharma Journal: J Health Popul Nutr Date: 2011-10 Impact factor: 2.000
Authors: Lea A Cupul-Uicab; Rolv Skjaerven; Kjell Haug; Kari K Melve; Stephanie M Engel; Matthew P Longnecker Journal: Environ Health Perspect Date: 2011-11-29 Impact factor: 9.031
Authors: C Zusi; E Rinaldi; S Bonetti; M L Boselli; E Trabetti; G Malerba; E Bonora; R C Bonadonna; M Trombetta Journal: J Endocrinol Invest Date: 2021-06-14 Impact factor: 4.256