| Literature DB >> 20042334 |
Ian Rilatt1, Etienne Mirabel, Bruno Le Grand, Michel Perez.
Abstract
High-throughput screening resulted in the identification of a small molecule inhibitor of PAR1. Optimisation of the initial hit led to the discovery of compounds 34 and 49, which displayed antithrombotic activity in an arteriovenous shunt model in the rat after iv administration. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
Mesh：
Substances：
Year: 2009 PMID： 20042334 DOI： 10.1016/j.bmcl.2009.12.072
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823