| Literature DB >> 20042272 |
Collin T Nguyen1, James T Nguyen, Steven Rutledge, Janing Zhang, Chen Wang, Gilbert C Walker.
Abstract
Selective targeting and detection of a hematologic malignancy, chronic lymphocytic leukemia, using surface enhanced Raman scattering (SERS) gold nanoparticles is reported. The functional nanoparticles were composed of a gold core onto which an optical reporter dye was adsorbed, protected from aggregation by grafted polyethyleneglycol, and targeted to CD19 antigen by antibodies. The signals were detected by dark-field microscopy and Raman spectrometry. The observation that the Raman signals are not disrupted by several traditional pathology stains indicates advantages over fluorescence methods. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20042272 DOI： 10.1016/j.canlet.2009.11.011
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679