Literature DB >> 20041340

Sphingosine-1-phosphate: a potential therapeutic agent against human breast cancer.

Binbing Ling1, Lifeng Chen, Jane Alcorn, Baohua Ma, Jian Yang.   

Abstract

Sphingosine-1-phosphate (S1P) is an important regulator of cancer development and progression. Its cellular concentration is controlled predominantly by sphingosine kinase (SK) and sphingosine-1-phosphate lyase (SPL). In the current study we showed that mRNA expressions for both SK and SPL were up-regulated throughout all four disease stages in human breast cancer patients. Exogenous administration of S1P produced a bell-shaped dose response for apoptosis in normal mammary gland MCF12A cells but a sigmoid-shaped apoptotic response in breast cancer MCF7 cells. Co-administration of S1P enhanced the cytotoxicity of anticancer drug docetaxel against MCF7 cells.

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Year:  2009        PMID： 20041340     DOI： 10.1007/s10637-009-9375-9

Source DB:  PubMed          Journal:  Invest New Drugs        ISSN： 0167-6997            Impact factor:   3.850


  26 in total

Review 1.  Studies of apoptosis in breast cancer.

Authors:  M Parton; M Dowsett; I Smith
Journal:  BMJ       Date:  2001-06-23

Review 2.  Sphingolipids in cancer: regulation of pathogenesis and therapy.

Authors:  Besim Ogretmen
Journal:  FEBS Lett       Date:  2006-09-05       Impact factor: 4.124

3.  Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol.

Authors:  Mika Ikeda; Akio Kihara; Yasuyuki Igarashi
Journal:  Biochem Biophys Res Commun       Date:  2004-12-03       Impact factor: 3.575

4.  Clinical trial of intrathecal administration of 5-fluoro-2'-deoxyuridine for treatment of meningeal dissemination of malignant tumors.

Authors:  H Nakagawa; M Yamada; N Maeda; K Iwatsuki; A Hirayama; K Ikenaka
Journal:  J Neurooncol       Date:  1999       Impact factor: 4.130

Review 5.  Clinical studies of apoptosis and proliferation in breast cancer.

Authors:  M Dowsett; C Archer; L Assersohn; R K Gregory; P A Ellis; J Salter; J Chang; P Mainwaring; I Boeddinghaus; S R Johnston; T J Powles; I E Smith
Journal:  Endocr Relat Cancer       Date:  1999-03       Impact factor: 5.678

6.  Effects of new endogenous nonprotein amino acids, 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives, on behavior of mice.

Authors:  H Nakagawa; N Nihonmatsu; S Ohta; M Hirobe
Journal:  Biochem Biophys Res Commun       Date:  1996-08-23       Impact factor: 3.575

Review 7.  Sphingosine kinase, sphingosine-1-phosphate, and apoptosis.

Authors:  Michael Maceyka; Shawn G Payne; Sheldon Milstien; Sarah Spiegel
Journal:  Biochim Biophys Acta       Date:  2002-12-30

8.  Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis.

Authors:  Ulrike Reiss; Babak Oskouian; Jianhui Zhou; Vinita Gupta; Prathap Sooriyakumaran; Samuel Kelly; Elaine Wang; Alfred H Merrill; Julie D Saba
Journal:  J Biol Chem       Date:  2003-10-21       Impact factor: 5.157

Review 9.  Endogenous beta-carbolines as clonidine-displacing substances.

Authors:  E S J Robinson; N J Anderson; J Crosby; D J Nutt; A L Hudson
Journal:  Ann N Y Acad Sci       Date:  2003-12       Impact factor: 5.691

Review 10.  Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator?

Authors:  Fumikazu Okajima
Journal:  Biochim Biophys Acta       Date:  2002-05-23
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  7 in total

Review 1.  Sphingosine kinase 1 in cancer.

Authors:  Linda A Heffernan-Stroud; Lina M Obeid
Journal:  Adv Cancer Res       Date:  2013       Impact factor: 6.242

2.  Preclinical study of the antitumor effect of sphingosine-1-phosphate receptor 1 antibody (S1PR1-antibody) against human breast cancer cells.

Authors:  Shujun Xiao; Jian Yang
Journal:  Invest New Drugs       Date:  2018-06-02       Impact factor: 3.850

Review 3.  Molecular Pharmacology and Novel Potential Therapeutic Applications of Fingolimod.

Authors:  Safura Pournajaf; Leila Dargahi; Mohammad Javan; Mohammad Hossein Pourgholami
Journal:  Front Pharmacol       Date:  2022-02-16       Impact factor: 5.810

4.  Synergistic Effect between Sphingosine-1-Phosphate and Chemotherapy Drugs against Human Brain-metastasized Breast Cancer MDA-MB-361 cells.

Authors:  Ahlam Sultan; Binbing Ling; Huihua Zhang; Baohua Ma; Deborah Michel; Jane Alcorn; Jian Yang
Journal:  J Cancer       Date:  2013-03-25       Impact factor: 4.207

5.  Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy.

Authors:  Ahmed M Abu El-Asrar; Mohd Imtiaz Nawaz; Ghulam Mohammad; Mohammad Mairaj Siddiquei; Kaiser Alam; Ahmed Mousa; Ghislain Opdenakker
Journal:  Lipids Health Dis       Date:  2014-12-11       Impact factor: 3.876

6.  Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway.

Authors:  Heba Alshaker; Jonathan Krell; Adam E Frampton; Jonathan Waxman; Oleg Blyuss; Alexey Zaikin; Mathias Winkler; Justin Stebbing; Ernesto Yagüe; Dmitri Pchejetski
Journal:  Breast Cancer Res       Date:  2014-10-25       Impact factor: 6.466

Review 7.  Sphingosine Kinase 1 in Breast Cancer-A New Molecular Marker and a Therapy Target.

Authors:  Heba Alshaker; Hannah Thrower; Dmitri Pchejetski
Journal:  Front Oncol       Date:  2020-03-20       Impact factor: 6.244
  7 in total

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