PURPOSE: Hyaluronic Acid (HA) has a role as "physiologic selector" for spermatozoa prior to intracytoplasmic sperm injection (ICSI). The objective of this study is to analyze the results achievable by the introduction of a routine HA-ICSI programme. METHODS: We retrospectively observed 293 couples treated with HA-ICSI versus 86 couples treated with conventional PVP-ICSI (historical control group). ICSI was performed on a limited number of oocytes per patient (1-3) according to Italian IVF law at the time of the study. Main outcome measures observed were: fertilization, embryo quality, implantation and pregnancy. RESULTS: This study showed that Injection of HA-bound spermatozoa (HA-ICSI) significantly improves embryo quality and implantation. CONCLUSIONS: If wider multi-center randomized studies will confirm these beneficial effects on ICSI outcome, HA could be considered as a routine choice for "physiologic" sperm selection prior to ICSI.
PURPOSE:Hyaluronic Acid (HA) has a role as "physiologic selector" for spermatozoa prior to intracytoplasmic sperm injection (ICSI). The objective of this study is to analyze the results achievable by the introduction of a routine HA-ICSI programme. METHODS: We retrospectively observed 293 couples treated with HA-ICSI versus 86 couples treated with conventional PVP-ICSI (historical control group). ICSI was performed on a limited number of oocytes per patient (1-3) according to Italian IVF law at the time of the study. Main outcome measures observed were: fertilization, embryo quality, implantation and pregnancy. RESULTS: This study showed that Injection of HA-bound spermatozoa (HA-ICSI) significantly improves embryo quality and implantation. CONCLUSIONS: If wider multi-center randomized studies will confirm these beneficial effects on ICSI outcome, HA could be considered as a routine choice for "physiologic" sperm selection prior to ICSI.
Authors: Giovanni Battista La Sala; Maria Teresa Villani; Alessia Nicoli; Barbara Valli; Francesca Iannotti; Isaac Blickstein Journal: Fertil Steril Date: 2007-08-06 Impact factor: 7.329
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Authors: María José Gómez-Torres; Natalia Huerta-Retamal; Paula Sáez-Espinosa; Laura Robles-Gómez; Manuel Avilés; Jon Aizpurua Journal: Reprod Sci Date: 2022-07-11 Impact factor: 2.924
Authors: K D Witt; L Beresford; S Bhattacharya; K Brian; A Coomarasamy; Rachel Cutting; R Hooper; J Kirkman-Brown; Y Khalaf; S E Lewis; A Pacey; S Pavitt; R West; D Miller Journal: BMJ Open Date: 2016-10-07 Impact factor: 2.692