Literature DB >> 20040819

Aluminum phosphide poisoning.

Viroj Wiwanitkit.   

Abstract

Entities:  

Year:  2009        PMID: 20040819      PMCID: PMC2823103          DOI: 10.4103/0972-5229.58547

Source DB:  PubMed          Journal:  Indian J Crit Care Med        ISSN: 0972-5229


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Sir, I read the recent publication by Jaiswal et al., on aluminium phosphide poisoning with great interest.[1] In their work,[1] correction of severe metabolic acidosis on patient outcome was studied. Jaiswal et al., noted that “there was significant improvement from 30.36% in the case when only half correction was done, as has been the common practice, to 57.5%, when full correction of metabolic acidosis was done.”[1] Indeed, aluminium phosphide poisoning is confirmed for induction of severe metabolic acidosis and relates to the high mortality. Khosla et al., noted that “severe metabolic acidosis was common and mortality was high (49%).”[2] The correction of metabolic acidosis seems to be the core therapeutic concept for aluminium phosphide poisoning. There is no doubt about the usefulness of this treatment. Several treatments are available at present, including gastric lavage with potassium permanganate solution, oral administration of charcoal and sorbitol suspension, intravenous administration of sodium bicarbonate, magnesium sulphate and calcium gluconate, and oral administration of sodium bicarbonate as well as alternative usage of oral administration of coconut oil.[3] No doubt that full correction of metabolic acidosis must be the aim of treatment since there is no reason to leave acidosis within the patient.
  3 in total

1.  Successful treatment of acute aluminium phosphide poisoning: possible benefit of coconut oil.

Authors:  Shahin Shadnia; Mojgan Rahimi; Abdolkarim Pajoumand; Mohammad-Hosein Rasouli; Mohammad Abdollahi
Journal:  Hum Exp Toxicol       Date:  2005-04       Impact factor: 2.903

2.  Aluminium phosphide poisoning.

Authors:  S N Khosla; R Handa; P Khosla
Journal:  Trop Doct       Date:  1992-10       Impact factor: 0.731

3.  Aluminum phosphide poisoning: effect of correction of severe metabolic acidosis on patient outcome.

Authors:  S Jaiswal; R K Verma; N Tewari
Journal:  Indian J Crit Care Med       Date:  2009 Jan-Mar
  3 in total

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