Literature DB >> 20040330

Lymphocytic hypophysitis with normal pituitary function mimicking a pituitary adenoma: a case report and review of literature.

M Rumana1, A Kirmani, N Khursheed, S Besina, M Khalil.   

Abstract

Lymphocytic hypophysitis (LYH) is a rare autoimmune inflammatory disorder of the pituitary gland usually affecting young women, often in pregnancy or post partum period. It is rare in non-pregnant females and in men. Patients present with symptoms of an expanding pituitary mass and/or varying degrees of pituitary dysfunction. We, hereby report a case of lymphocytic hypophysitis in a 28-year-old non-pregnant female who presented with clinical and radiological features of a pituitary tumor with normal pituitary hormones which on histopathological examination revealed features of lymphocytic hypophysitis. The case is presented here for its rarity and its unique presentation as an expanding pituitary mass with normal pituitary function. Peculiar clinical, radiological and histopathological features of this uncommon entity are discussed.

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Year:  2010        PMID: 20040330     DOI: 10.5414/npp29026

Source DB:  PubMed          Journal:  Clin Neuropathol        ISSN: 0722-5091            Impact factor:   1.368


  4 in total

Review 1.  Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions.

Authors:  Sriram Gubbi; Fady Hannah-Shmouni; Constantine A Stratakis; Christian A Koch
Journal:  Rev Endocr Metab Disord       Date:  2018-12       Impact factor: 6.514

2.  Corticosteroid treatment buys time in case of a newly diagnosed hypophysitis with visual deterioration.

Authors:  Marike Broekman; Stephan Hendrik Goedee; Willy-Anne Nieuwlaat; Paul Depauw
Journal:  BMJ Case Rep       Date:  2013-09-13

3.  Pregnancy and pituitary disorders: Challenges in diagnosis and management.

Authors:  Bashir A Laway; Shahnaz A Mir
Journal:  Indian J Endocrinol Metab       Date:  2013-11

4.  Primary central nervous system vasculitis preceded by granulomatous hypophysitis: Case report with a review of the literature.

Authors:  Meng Huang; William J Steele; David S Baskin
Journal:  Surg Neurol Int       Date:  2015-09-28
  4 in total

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