| Literature DB >> 20039272 |
Michel F P van der Jagt1, Theo Wobbes, Luc J A Strobbe, Fred C G J Sweep, Paul N Span.
Abstract
Metalloproteinases (MPs) such as the matrix metalloproteinases (MMPs) and adamalysins (ADAMs and ADAMTS) are expressed in various stages of colorectal cancer (CRC), and some correlate with survival and prognosis. The MPs are regulated by various factors including EMMPRIN, TIMPs, and RECK. In addition, micro-RNAs are found to be relevant for both MP expression levels and CRC prognostication. Both MPs and their regulators could be potential targets for intervention and therapy in CRC. (c) 2009 Wiley-Liss, Inc.Entities:
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Year: 2010 PMID: 20039272 DOI: 10.1002/jso.21462
Source DB: PubMed Journal: J Surg Oncol ISSN: 0022-4790 Impact factor: 3.454