| Literature DB >> 20038128 |
Taridaporn Bunyapaiboonsri1, Seangaroon Yoiprommarat, Prasert Srikitikulchai, Kitlada Srichomthong, Saisamorn Lumyong.
Abstract
Six new oblongolides, W1, W2, X, Y, and Z (1-3, 6, 7) and 2-deoxy-4alpha-hydroxyoblongolide X (4), and the known compounds oblongolide (8), oblongolides T, C, and Q (5, 9, 10), and (-)-5-methylmellein were isolated from the endophytic fungus Phomopsis sp. BCC 9789. Compound 7 showed anti-HSV-1 activity (IC50=14 microM) and cytotoxic activities against KB, BC, NCI-H187, and nonmalignant (Vero) cell lines with respective IC50 values of 37, 26, 32, and 60 microM. Cytotoxic activity against the BC cell line was also observed for compound 6, with an IC50 value of 48 microM.Entities:
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Year: 2010 PMID： 20038128 DOI： 10.1021/np900650c
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050