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Literature DB >> 20037816

Interaction among Rb/p16, Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma.

Abstract

The mechanism and interaction among Rb/p16, Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma were investigated. By using the immunoprecipitation method, the interactions among Rb, p16, E2F1, HDAC1 proteins in gallbladder carcinoma cell line (Mz-ChA-1) were studied. It was found that there were Rb and E2F1 proteins in the precipitates with anti-HDAC1, and there were HDAC1 and E2F1 proteins in the precipitate with anti-Rb. It was concluded that there are specific interactions among Rb, HDAC1 and E2F1 proteins in gallbladder carcinoma, indicating the existence of the direct Rb/E2F1/HDAC1 signal transduction pathway. There is no direct relationship between p16 proteins with Rb, HDAC1, and E2F1 proteins.

Entities: Disease Gene

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Year: 2009 PMID： 20037816 DOI： 10.1007/s11596-009-0611-5

Source DB: PubMed Journal: J Huazhong Univ Sci Technolog Med Sci ISSN： 1672-0733

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References

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Interaction among Rb/p16, Rb/E2F1 and HDAC1 proteins in gallbladder carcinoma.

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