| Literature DB >> 20036534 |
Hui Tang1, Canhui Zheng, Jiaguo Lv, Juan Wu, Yanan Li, Hui Yang, Bingyue Fu, Chuntong Li, Youjun Zhou, Ju Zhu.
Abstract
A series of novel pyrazino[2,1-a]isoquinolin compounds were designed and synthesized, and their antifungal activities in vitro were evaluated. The results showed that all of the compounds exhibited antifungal activities. Some of them exhibited stronger antifungal activities than that of lead compounds and among them compound 11b was the most potent one, which showed more potent than that of the active control fluconazole to the four of the five tested fungi. The studies presented here provide a new structural type for the development of novel antifungal agents. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20036534 DOI： 10.1016/j.bmcl.2009.12.050
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823