| Literature DB >> 20036447 |
Radek Gazák1, Katerina Purchartová, Petr Marhol, Lucie Zivná, Petr Sedmera, Katerina Valentová, Nobuo Kato, Hiroyo Matsumura, Kunihiro Kaihatsu, Vladimír Kren.
Abstract
Two selective acylation methods for silybin esterification with long-chain fatty acids were developed, yielding a series of silybin 7-O- and 23-O-acyl-derivatives of varying acyl chain lengths. These compounds were tested for their antioxidant (inhibition of lipid peroxidation and DPPH-scavenging) and anti-influenza virus activities. The acyl chain length is an important prerequisite for both biological activities, as they improved with increasing length of the acyl moiety. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.Entities:
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Year: 2009 PMID： 20036447 DOI： 10.1016/j.ejmech.2009.11.056
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514