| Literature DB >> 20036121 |
Julianne A Hunt1, Silvia Gonzalez, Florida Kallashi, Milton L Hammond, James V Pivnichny, Xinchun Tong, Suoyu S Xu, Matt S Anderson, Ying Chen, Suzanne S Eveland, Qiu Guo, Sheryl A Hyland, Denise P Milot, Carl P Sparrow, Samuel D Wright, Peter J Sinclair.
Abstract
The development of a series of 2-arylbenzoxazole alpha-alkoxyamide and beta-alkoxyamine inhibitors of cholesteryl ester transfer protein (CETP) is described. Highly fluorinated alpha-alkoxyamides proved to be potent inhibitors of CETP in vitro, and the highly fluorinated 2-arylbenzoxazole beta-alkoxyamine 4 showed a desirable combination of in vitro potency (IC(50)=151 nM) and oral bioavailability in the mouse. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20036121 DOI： 10.1016/j.bmcl.2009.12.046
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823