| Literature DB >> 20036020 |
Laurence Bal1, Stéphane Ederhy1, Emanuele Di Angelantonio1, Florence Toti2, Fatiha Zobairi2, Ghislaine Dufaitre1, Catherine Meuleman1, Ziad Mallat3, Franck Boccara1, Alain Tedgui3, Jean Marie Freyssinet2, Ariel Cohen4.
Abstract
We investigated whether circulating procoagulant microparticles (CPMPs) contributed to hypercoagulability in 45 patients with acute pulmonary embolism (APE) and in 45 controls with and 45 controls without cardiovascular risk factors. Concentrations of CPMPs and platelet-derived microparticles (PMPs) were statistically significantly higher in patients with APE than in controls without cardiovascular risk factors. PMPs appeared to be the main source of procoagulant microparticle release in APE, but this correlation disappeared when APE patients were compared to controls with cardiovascular risk factors. CPMPs may have a role in venous thrombosis as mediators of cardiovascular risk factors.Entities:
Mesh:
Year: 2009 PMID: 20036020 DOI: 10.1016/j.ijcard.2009.11.048
Source DB: PubMed Journal: Int J Cardiol ISSN: 0167-5273 Impact factor: 4.164