| Literature DB >> 20036004 |
Beibei Zhou1, Jun Leng, Meng Hu, Li Zhang, Zhan Wang, Dongying Liu, Xiaoling Tong, Beibei Yu, Yi Hu, Chaohua Deng, Yanping Liu, Qiuping Zhang.
Abstract
Chemokines and their corresponding receptors participate in transmigration of leukemic cells. ERM (ezrin/radixin/moesin) protein family act as linkers between the plasma membrane and the cytoskeleton and are key component in tumor metastasis. In this study we used the CCR9-expressing acute T lymphocytic cell line MOLT4 as a model and assesssed their morphological and functional changes in response to CCL25. The pseudopodium formed and ERM translocated from the cytoplasm to the cell membrane following treatment with CCL25. Ezrin silencing by miRNA showed that ezrin plays important roles in the polarization and invasive behaviour of MOLT4 cells. Copyright 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20036004 DOI： 10.1016/j.leukres.2009.11.025
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156