| Literature DB >> 20035556 |
Chew-Yan Gan1, Yun-Yee Low, Tadahiro Etoh, Masahiko Hayashi, Kanki Komiyama, Toh-Seok Kam.
Abstract
Seven new indole alkaloids of the Strychnos type, leuconicines A-G (1-7), and a new eburnan alkaloid, (-)-eburnamaline (8), were isolated from the stem-bark extract of two Malayan Leuconotis species. The structures of these alkaloids were established using NMR and MS analysis and in the case of 8 also by partial synthesis. Alkaloids 1-5 reversed multidrug resistance in vincristine-resistant KB cells.Entities:
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Year: 2009 PMID： 20035556 DOI： 10.1021/np900576b
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050