Meika Foster1, Peter Petocz, Samir Samman. 1. Discipline of Nutrition and Metabolism, School of Molecular and Microbial Biosciences, University of Sydney NSW 2006, Australia.
Abstract
BACKGROUND: Studies in humans and animals suggest that zinc has the potential to affect lipoprotein metabolism and hence impact cardiovascular disease risk. METHODS: A meta-analysis of controlled clinical trials was conducted to determine the effect of zinc supplementation on plasma cholesterol and triglyceride concentrations in humans. Potentially relevant studies were identified from a literature search covering the period 1980-2008 (inclusive), and additional citation searches. RESULTS: Thirty three interventions (n=14,238 subjects) were included in the random effects meta-analysis. No overall significant effects of zinc supplementation were observed for plasma cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol or plasma triglyceride concentrations. Plasma zinc concentrations increased significantly (+2.42+/-0.25 micromol/L, P<0.001; n=14,047). Secondary analyses in individuals classified as healthy revealed that zinc supplementation is associated with a significant decrease in plasma HDL cholesterol concentrations (-0.10+/-0.02 mmol/L, P<0.001; n=13,215), equivalent to a 7% decrease from baseline. CONCLUSION: No effect of zinc supplementation on plasma lipoproteins was detected in the overall analysis. In individuals classified as healthy, zinc supplementation is associated with a decrease in HDL cholesterol concentrations and thus contributes to an increased risk of coronary heart disease. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
BACKGROUND: Studies in humans and animals suggest that zinc has the potential to affect lipoprotein metabolism and hence impact cardiovascular disease risk. METHODS: A meta-analysis of controlled clinical trials was conducted to determine the effect of zinc supplementation on plasma cholesterol and triglyceride concentrations in humans. Potentially relevant studies were identified from a literature search covering the period 1980-2008 (inclusive), and additional citation searches. RESULTS: Thirty three interventions (n=14,238 subjects) were included in the random effects meta-analysis. No overall significant effects of zinc supplementation were observed for plasma cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol or plasma triglyceride concentrations. Plasma zinc concentrations increased significantly (+2.42+/-0.25 micromol/L, P<0.001; n=14,047). Secondary analyses in individuals classified as healthy revealed that zinc supplementation is associated with a significant decrease in plasma HDL cholesterol concentrations (-0.10+/-0.02 mmol/L, P<0.001; n=13,215), equivalent to a 7% decrease from baseline. CONCLUSION: No effect of zinc supplementation on plasma lipoproteins was detected in the overall analysis. In individuals classified as healthy, zinc supplementation is associated with a decrease in HDL cholesterol concentrations and thus contributes to an increased risk of coronary heart disease. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.
Authors: M L Mispireta; L E Caulfield; N Zavaleta; M Merialdi; D L Putnick; M H Bornstein; J A DiPietro Journal: J Dev Orig Health Dis Date: 2016-10-17 Impact factor: 2.401
Authors: R Jayawardena; P Ranasinghe; P Galappatthy; Rldk Malkanthi; Gr Constantine; P Katulanda Journal: Diabetol Metab Syndr Date: 2012-04-19 Impact factor: 3.320