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Literature DB >> 20034552

Mechanisms of hematopoietic stem cell aging.

Abstract

New blood cells are continually produced from the hematopoietic stem cells (HSCs) that reside in the bone marrow. Throughout the life-span of the organism, this stem cell reservoir sustains life. Although HSCs can persist in vivo longer than one life-span (Harrison et al., 1978), with aging, HSC regenerative potential diminishes and skewing from lymphopoiesis toward myelopoiesis occurs. The expansion in the HSC pool with aging provides sufficient, yet abnormal, blood production. Examination of gene expression changes in aged HSCs has provided a link between aging and genomic instability. Furthermore, studies on the effects of reactive oxygen species (ROS) on HSC aging has given more insight into the reasons for HSC failure. Understanding of the interactions between niche cells and HSCs and changes in them with aging, may give us insights into the lineage skewing phenotype observed in the aged, and also other immune dysfunctions. 2009 Elsevier Inc. All rights reserved.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Reactive Oxygen Species

Year: 2009 PMID： 20034552 PMCID： PMC3632712 DOI： 10.1016/j.exger.2009.12.010

Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032

35 in total

1. The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets.

Authors: Hans B Sieburg; Rebecca H Cho; Brad Dykstra; Naoyuki Uchida; Connie J Eaves; Christa E Muller-Sieburg
Journal: Blood Date: 2005-11-15 Impact factor: 22.113

2. Rejuvenation of aged progenitor cells by exposure to a young systemic environment.

Authors: Irina M Conboy; Michael J Conboy; Amy J Wagers; Eric R Girma; Irving L Weissman; Thomas A Rando
Journal: Nature Date: 2005-02-17 Impact factor: 49.962

3. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells.

Authors: Mark J Kiel; Omer H Yilmaz; Toshihide Iwashita; Osman H Yilmaz; Cox Terhorst; Sean J Morrison
Journal: Cell Date: 2005-07-01 Impact factor: 41.582

Review 4. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans.

Authors: Claudio Franceschi; Miriam Capri; Daniela Monti; Sergio Giunta; Fabiola Olivieri; Federica Sevini; Maria Panagiota Panourgia; Laura Invidia; Laura Celani; Maria Scurti; Elisa Cevenini; Gastone C Castellani; Stefano Salvioli
Journal: Mech Ageing Dev Date: 2006-11-20 Impact factor: 5.432

5. The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion.

Authors: Leonie M Kamminga; Leonid V Bystrykh; Aletta de Boer; Sita Houwer; José Douma; Ellen Weersing; Bert Dontje; Gerald de Haan
Journal: Blood Date: 2005-11-17 Impact factor: 22.113

Review 6. P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis.

Authors: Ming Chen; Jian-Guo Geng
Journal: Arch Immunol Ther Exp (Warsz) Date: 2006-03-24 Impact factor: 4.291

7. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells.

Authors: Ying Liang; Gary Van Zant; Stephen J Szilvassy
Journal: Blood Date: 2005-04-12 Impact factor: 22.113

8. Increased hematopoietic stem cell mobilization in aged mice.

Authors: Zhenlan Xing; Marnie A Ryan; Deidre Daria; Kalpana J Nattamai; Gary Van Zant; Lei Wang; Yi Zheng; Hartmut Geiger
Journal: Blood Date: 2006-06-01 Impact factor: 22.113

9. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus.

Authors: J J Jacobs; K Kieboom; S Marino; R A DePinho; M van Lohuizen
Journal: Nature Date: 1999-01-14 Impact factor: 49.962

10. Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice.

Authors: Hideyuki Oguro; Atsushi Iwama; Yohei Morita; Takehiko Kamijo; Maarten van Lohuizen; Hiromitsu Nakauchi
Journal: J Exp Med Date: 2006-09-05 Impact factor: 14.307

33 in total

Review 1. Rejuvenation of aged hematopoietic stem cells.

Authors: Novella Guidi; Hartmut Geiger
Journal: Semin Hematol Date: 2016-10-24 Impact factor: 3.851

2. Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing.

Authors: Aysegul V Ergen; Nathan C Boles; Margaret A Goodell
Journal: Blood Date: 2012-01-30 Impact factor: 22.113

Review 3. The importance of hypoxia and extra physiologic oxygen shock/stress for collection and processing of stem and progenitor cells to understand true physiology/pathology of these cells ex vivo.

Authors: Hal E Broxmeyer; Heather A O'Leary; Xinxin Huang; Charlie Mantel
Journal: Curr Opin Hematol Date: 2015-07 Impact factor: 3.284

4. Transient CDK4/6 inhibition protects hematopoietic stem cells from chemotherapy-induced exhaustion.

Authors: Shenghui He; Patrick J Roberts; Jessica A Sorrentino; John E Bisi; Hannah Storrie-White; Renger G Tiessen; Karenann M Makhuli; William A Wargin; Henko Tadema; Ewoud-Jan van Hoogdalem; Jay C Strum; Rajesh Malik; Norman E Sharpless
Journal: Sci Transl Med Date: 2017-04-26 Impact factor: 17.956