| Literature DB >> 200329 |
R M Bannatyne, N M Harnett, R Cheung.
Abstract
The mouse model of intraperitoneal meningococcal sepsis was used to evaluate the antiendotoxic activity of polymyxin B sulfate independent of its antibiotic effects. Administered either before or after the infective challenge therapeutic doses of polymyxin B sulfate produced small but significant increases in survival over unprotected animals. These results also suggest that endotoxin contributes to the outcome in this variety of Gram-negative infection.Entities:
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Year: 1977 PMID： 200329 DOI： 10.1139/m77-226
Source DB: PubMed Journal: Can J Microbiol ISSN： 0008-4166 Impact factor: 2.419