INTRODUCTION:Bevacizumab (B) improves survival of patients with metastatic, nonsquamous non-small cell lung cancer. Based on encouraging results from preclinical studies combining B with sunitinib (S), a phase II, randomized, open-label study (Study Assessing the Blockade of both VEGF Receptor and ligand to enhance Efficacy in Lung) was initiated to assess clinical outcomes of adding S to paclitaxel (P)/carboplatin (C) + B (PCB) for first-line treatment of locally advanced, metastatic, or recurrent nonsquamous non-small cell lung cancer. METHODS: Study enrollment was to occur in three phases. In the first phase, patients received PC + B (15 mg/kg every 3 weeks), +/-S (25 mg daily, 2 weeks on, 1 week off). If tolerated, the second phase would include a third cohort receiving 37.5 mg S. The third phase would consist of PCB +/- highest tolerable dose S. RESULTS:Between March 2007 and January 2008, 26 patients were randomized to receive PCB and 30 to PCB + S 25 mg. Because of poor tolerability, none of the patients were escalated to 37.5 mg S. Median treatment duration was 10.3 weeks for PCB and 6.0 weeks for PCB + S. Thirty-five percent of patients on PCB + S required S dose reduction, 52% required S treatment interruption, and 59% discontinued S because of adverse events, most frequently hematologic events (neutropenia, thrombocytopenia, and leukopenia) and fatigue. Patients receiving PCB + S required more B interruptions (38% versus 19% for PCB) and discontinuation (52% versus 35%) because of adverse events. Survival data were limited by small sample sizes and limited treatment duration. Overall survival was not mature at time of analysis: median 6.6 months for PCB + S and not reached for PCB. Two out of 25 efficacy-evaluable patients randomized to the PCB + S cohort had confirmed partial responses, compared with 5 of 19 randomized to the PCB cohort. CONCLUSIONS: The addition of S to PCB was not well tolerated because of toxicities. This combination should not be studied further at these doses and schedules.
RCT Entities:
INTRODUCTION:Bevacizumab (B) improves survival of patients with metastatic, nonsquamous non-small cell lung cancer. Based on encouraging results from preclinical studies combining B with sunitinib (S), a phase II, randomized, open-label study (Study Assessing the Blockade of both VEGF Receptor and ligand to enhance Efficacy in Lung) was initiated to assess clinical outcomes of adding S to paclitaxel (P)/carboplatin (C) + B (PCB) for first-line treatment of locally advanced, metastatic, or recurrent nonsquamous non-small cell lung cancer. METHODS: Study enrollment was to occur in three phases. In the first phase, patients received PC + B (15 mg/kg every 3 weeks), +/-S (25 mg daily, 2 weeks on, 1 week off). If tolerated, the second phase would include a third cohort receiving 37.5 mg S. The third phase would consist of PCB +/- highest tolerable dose S. RESULTS: Between March 2007 and January 2008, 26 patients were randomized to receive PCB and 30 to PCB + S 25 mg. Because of poor tolerability, none of the patients were escalated to 37.5 mg S. Median treatment duration was 10.3 weeks for PCB and 6.0 weeks for PCB + S. Thirty-five percent of patients on PCB + S required S dose reduction, 52% required S treatment interruption, and 59% discontinued S because of adverse events, most frequently hematologic events (neutropenia, thrombocytopenia, and leukopenia) and fatigue. Patients receiving PCB + S required more B interruptions (38% versus 19% for PCB) and discontinuation (52% versus 35%) because of adverse events. Survival data were limited by small sample sizes and limited treatment duration. Overall survival was not mature at time of analysis: median 6.6 months for PCB + S and not reached for PCB. Two out of 25 efficacy-evaluable patients randomized to the PCB + S cohort had confirmed partial responses, compared with 5 of 19 randomized to the PCB cohort. CONCLUSIONS: The addition of S to PCB was not well tolerated because of toxicities. This combination should not be studied further at these doses and schedules.
Authors: David E Gerber; Paul Swanson; Ariel Lopez-Chavez; Lucas Wong; Afshin Dowlati; Nathan A Pennell; Damien M Cronier; Amy Qin; Robert Ilaria; Jan Cosaert; Ashwin Shahir; Maria Q Baggstrom Journal: Lung Cancer Date: 2017-07-18 Impact factor: 5.705
Authors: Lingna Li; Tom A Leedom; Janet Do; Hanhua Huang; JingYu Lai; Kim Johnson; Trina F Osothprarop; John D Rizzo; Venkata R Doppalapudi; Curt W Bradshaw; Rodney W Lappe; Gary Woodnutt; Nancy J Levin; Steven R Pirie-Shepherd Journal: Transl Oncol Date: 2011-08-01 Impact factor: 4.243
Authors: R D Harvey; T K Owonikoko; C M Lewis; A Akintayo; Z Chen; M Tighiouart; S S Ramalingam; M P Fanucchi; P Nadella; A Rogatko; D M Shin; B El-Rayes; F R Khuri; J S Kauh Journal: Br J Cancer Date: 2013-01-15 Impact factor: 7.640